Synthesis, Optimization, ADME Analysis, and Antioxidant Activity of 2-(Arylethynyl)-3-ethynylthiophenes

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dc.authoridYILMAZ, Can/0000-0002-0028-6614
dc.authoridKivrak, Arif/0000-0003-4770-2686
dc.authoridKavak, Emrah/0000-0002-6161-2030
dc.authoridKONUS, METIN/0000-0002-9953-1375
dc.contributor.authorKavak, E.
dc.contributor.authorAlgso, M. A. S.
dc.contributor.authorKonus, M.
dc.contributor.authorYilmaz, C.
dc.contributor.authorLazoglu, A.
dc.contributor.authorKaraagac, S. U.
dc.contributor.authorKivrak, A.
dc.date.accessioned2024-09-29T16:04:45Z
dc.date.available2024-09-29T16:04:45Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstract2,3-Dialkynylthiophene derivatives were synthesized by using regio- and stereocontrolled Pd-catalyzed Sonogashira coupling and desilylation reactions. The synthesized compounds were analyzed in silico for their pharmacokinetic parameters, general toxicity, and drug scores. In particular, 3-ethynyl-2-(phenylethynyl)thiophene and 3-ethynyl-2-[(4-methylphenyl)ethynyl]thiophene were found to have relatively high drug scores and low toxicities. The antioxidant activity of the title compounds were evaluated by five different assays. 3-Ethynyl-2-(naphthalen-1-ylethynyl)thiophene displayed significant reducing and free radical scavenging activities.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [114Z042]; Van Yuzuncu Yil University [FYL-2016-5243, FYL-2018-7439]; COST Action Challenging Organic Syntheses Inspired by Nature from Natural Products Chemistry to Drug Discovery [CM1407]; COST Action New Diagnostic and Therapeutic Tools Against Multidrug Resistant Tumors [CA17104]en_US
dc.description.sponsorshipThe authors thank The Scientific and Technological Research Council of Turkey (project no. 114Z042) for providing microwave reactor and chemicals and Van Yuzuncu Yil University (FYL-2016-5243; synthesis of compounds; FYL-2018-7439, financial support). A. Kivrak, C. Yilmaz, and M. Konus would like to acknowledge networking contribution by the COST Action CM1407 Challenging Organic Syntheses Inspired by Nature from Natural Products Chemistry to Drug Discovery. A. Kivrak also would like to acknowledge networking contribution by the COST Action CA17104 New Diagnostic and Therapeutic Tools Against Multidrug Resistant Tumors.en_US
dc.identifier.doi10.1134/S1070428021010139
dc.identifier.endpage99en_US
dc.identifier.issn1070-4280
dc.identifier.issn1608-3393
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85101779491en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage91en_US
dc.identifier.urihttps://doi.org/10.1134/S1070428021010139
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6308
dc.identifier.volume57en_US
dc.identifier.wosWOS:000621823200013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMaik Nauka/Interperiodica/Springeren_US
dc.relation.ispartofRussian Journal of Organic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectthiopheneen_US
dc.subjectcoupling reactionsen_US
dc.subjectheteroaromatic compoundsen_US
dc.subjectADMEen_US
dc.subjectantioxidantsen_US
dc.titleSynthesis, Optimization, ADME Analysis, and Antioxidant Activity of 2-(Arylethynyl)-3-ethynylthiophenesen_US
dc.typeArticleen_US

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