Cyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: Protective role of boron

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dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.authoridBilici, Namik/0000-0002-8747-4713
dc.authoridCETIK YILDIZ, Songul/0000-0002-7855-5343
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorSahinturk, Varol
dc.contributor.authorYildiz, Songul Cetik
dc.contributor.authorSahin, Ilknur Kulcanay
dc.contributor.authorBilici, Namik
dc.contributor.authorYaman, Suzan Onur
dc.contributor.authorAltuner, Yilmaz
dc.date.accessioned2024-09-29T15:57:47Z
dc.date.available2024-09-29T15:57:47Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: Cyclophosphamide (CP) is an alkylating chemotherapeutic drug used in the treatment of many types of cancer. However, as with other chemotherapeutic drugs, the use of CP is limited by the damage to healthy tissues such as testes, bladder and liver as well as cancerous tissue. Boron (B) is a trace element with many biological properties such as antioxidant, anti-apoptotic and anti-lipid per oxidation. Methods: This current study aims to determine protective effects of B on CP induced testicular toxicity. The rats were divided into 4 groups (control, CP, B and B plus CP groups). The testes of experimental animals were taken for histological, apoptotic markers and biochemical analysis. Results: The damage to some seminifer tubules, loss of typical appearance, thinning of seminifer epithelium and relative enlargement of the tubule lumen were watched in testis of the group that administrated CP. Moreover, Bcl-2, TAC and GSH levels decreased while TOC, OSI, MDA, Bax and Caspase-3 levels increased. On the other hand, pretreatment limited to B in the B plus CP group, testicular tissue improved. In addition, Bcl-2, GSH, TAC levels increased, Bax, MDA, TOC, OSI and caspase-3 levels decreased. Conclusion: B significantly reduced testicular lipid per-oxidation and strengthened antioxidant defenses. Our results showed that pre-treatment B can protect rat testis against CP-induced testicular damage owing to its anti-lipid per oxidation, anti-oxidant and anti-apoptotic properties.en_US
dc.identifier.doi10.1016/j.jtemb.2020.126574
dc.identifier.issn0946-672X
dc.identifier.issn1878-3252
dc.identifier.pmid32516632en_US
dc.identifier.scopus2-s2.0-85085993113en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2020.126574
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5016
dc.identifier.volume62en_US
dc.identifier.wosWOS:000586028000015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofJournal of Trace Elements in Medicine and Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclophosphamideen_US
dc.subjectTesticular damageen_US
dc.subjectApoptosisen_US
dc.subjectBoronen_US
dc.subjectAnti-Oxidanten_US
dc.subjectLipid per oxidationen_US
dc.titleCyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: Protective role of boronen_US
dc.typeArticleen_US

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