Is subgroup analysis of intermediate-risk non-muscle invasive bladder cancer important in predicting recurrence?
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
INTRODUCTION: We aimed to create subgroups in terms of tumor size, number and previous recurrencestatus in intermediate-risk non-muscle invasive bladder cancer (NMIBC) and evaluate the predictive roles ofthese parameters in determining recurrence.MATERIAL and METHODS: 99 patients who were treated and followed up between January 2009 andDecember 2015 with the diagnosis of intermediate-risk NMIBC were retrospectively analyzed. Group Iconsisted of primary, single, Ta grade, low grade, larger than 3 cm (> 3 cm) tumors; Group II consisted ofprimary, Ta grade, low grade, smaller than 3 cm (<3 cm), multiple tumors and Group III consisted of recurrenceof previous low-risk tumors. Three groups were compared in terms of clinical, pathological findings andrecurrence in follow-up.RESULTS: Mean age of patients was 65.73±12.21. Among them, 41 (41.4%) patients had recurrence in median48 (15-84) monthly follow-up. Recurrence rate in Group III (58.8%) was significantly higher than Group I(29.6%) and Group II (34.2%) (p = 0.039). The predicted recurrence-free survival (36.1 months) in Group IIIwas significantly lower than Group I (54.8 months) and Group II (61.2 months) (p=0.01 and p=0.003,respectively). In univariate analysis, the presence of previous recurrence, tumor size, number and CUETO score were reported as independent predictive factors for recurrence. In multivariate analysis, only the presence ofprevious recurrence was found to be significant.DISCUSSION and CONCLUSION: The subgroup analysis of intermediate-risk NMIBC may be helpful indetermining tumor treatment and follow-up protocols.We state that new tumor recurrences may be higher inintermediate-risk NMIBC with previous recurrence history.
Açıklama
Anahtar Kelimeler
Tıbbi İnformatik, Genel ve Dahili Tıp, Temel Sağlık Hizmetleri, Onkoloji, Sağlık Bilimleri ve Hizmetleri
Kaynak
ACTA ONCOLOGICA TURCICA
WoS Q Değeri
Scopus Q Değeri
Cilt
52
Sayı
1
