Is subgroup analysis of intermediate-risk non-muscle invasive bladder cancer important in predicting recurrence?

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dc.contributor.authorSelvı, İsmail
dc.contributor.authorÖztürk, Erdem
dc.date.accessioned2024-09-29T16:33:25Z
dc.date.available2024-09-29T16:33:25Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractINTRODUCTION: We aimed to create subgroups in terms of tumor size, number and previous recurrencestatus in intermediate-risk non-muscle invasive bladder cancer (NMIBC) and evaluate the predictive roles ofthese parameters in determining recurrence.MATERIAL and METHODS: 99 patients who were treated and followed up between January 2009 andDecember 2015 with the diagnosis of intermediate-risk NMIBC were retrospectively analyzed. Group Iconsisted of primary, single, Ta grade, low grade, larger than 3 cm (> 3 cm) tumors; Group II consisted ofprimary, Ta grade, low grade, smaller than 3 cm (<3 cm), multiple tumors and Group III consisted of recurrenceof previous low-risk tumors. Three groups were compared in terms of clinical, pathological findings andrecurrence in follow-up.RESULTS: Mean age of patients was 65.73±12.21. Among them, 41 (41.4%) patients had recurrence in median48 (15-84) monthly follow-up. Recurrence rate in Group III (58.8%) was significantly higher than Group I(29.6%) and Group II (34.2%) (p = 0.039). The predicted recurrence-free survival (36.1 months) in Group IIIwas significantly lower than Group I (54.8 months) and Group II (61.2 months) (p=0.01 and p=0.003,respectively). In univariate analysis, the presence of previous recurrence, tumor size, number and CUETO score were reported as independent predictive factors for recurrence. In multivariate analysis, only the presence ofprevious recurrence was found to be significant.DISCUSSION and CONCLUSION: The subgroup analysis of intermediate-risk NMIBC may be helpful indetermining tumor treatment and follow-up protocols.We state that new tumor recurrences may be higher inintermediate-risk NMIBC with previous recurrence history.en_US
dc.identifier.endpage183en_US
dc.identifier.issn0304-596X
dc.identifier.issue1en_US
dc.identifier.startpage177en_US
dc.identifier.trdizinid314693en_US
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/314693
dc.identifier.urihttps://hdl.handle.net/20.500.14619/11870
dc.identifier.volume52en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofACTA ONCOLOGICA TURCICAen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTıbbi İnformatiken_US
dc.subjectGenel ve Dahili Tıpen_US
dc.subjectTemel Sağlık Hizmetlerien_US
dc.subjectOnkolojien_US
dc.subjectSağlık Bilimleri ve Hizmetlerien_US
dc.titleIs subgroup analysis of intermediate-risk non-muscle invasive bladder cancer important in predicting recurrence?en_US
dc.typeArticleen_US

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