Effects of hyaluronic acid and gamma-radiated mineralized allografts on the healing of rat tibial defects
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cukurova Univ, Fac Medicine
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: This study aimed to evaluate the effects of hyaluronic acid (HyA) and gamma-radiated mineralized allografts (Gr-MAs) on the healing of bone defects in rat tibiae. Materials and Methods: Fifty-two male Sprague Dawley rats were randomly allocated to four groups: Gr-MA, HyA, Gr-MA combined with HyA (Gr-MA + HyA), and controls with empty defects. The animals were sacrificed on the 7th and 21st postoperative days. The inflammation, necrosis, fibrosis, new bone formation, and bone healing scores were evaluated on the basis of the histopathological findings. Results: The amount of new bone formation was found to be significantly greater in the control group than in the experimental groups. In addition, the healing scores were statistically higher in the control and the Gr-MA + HyA groups. Comparisons of the control, graft, and HyA groups indicated that the control group exhibited significantly less necrosis on the 7th day; however, on the 21st day, there were no statistically significant differences among the groups. There were no statistically significant differences among the groups in terms of the inflammation and fibrosis levels on the 7th or 21st days. Conclusion: Within the limitations of this study, the application of HyA alone and the addition of HyA to Gr-MA did not improve bone regeneration in rat tibial defects.
Açıklama
Anahtar Kelimeler
Hyaluronic acid, bone grafting, bone regeneration, bone formation, rats
Kaynak
Cukurova Medical Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
45
Sayı
2
