Effects of hyaluronic acid and gamma-radiated mineralized allografts on the healing of rat tibial defects

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dc.authoridOlgac, Vakur/0000-0003-0497-0314
dc.authoridCebi, Ahmet Taylan/0000-0001-9083-7215
dc.contributor.authorGas, Selin
dc.contributor.authorOlgac, Necat Vakur
dc.contributor.authorCebi, Ahmet Taylan
dc.contributor.authorKasapoglu, Cetin
dc.date.accessioned2024-09-29T16:06:33Z
dc.date.available2024-09-29T16:06:33Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPurpose: This study aimed to evaluate the effects of hyaluronic acid (HyA) and gamma-radiated mineralized allografts (Gr-MAs) on the healing of bone defects in rat tibiae. Materials and Methods: Fifty-two male Sprague Dawley rats were randomly allocated to four groups: Gr-MA, HyA, Gr-MA combined with HyA (Gr-MA + HyA), and controls with empty defects. The animals were sacrificed on the 7th and 21st postoperative days. The inflammation, necrosis, fibrosis, new bone formation, and bone healing scores were evaluated on the basis of the histopathological findings. Results: The amount of new bone formation was found to be significantly greater in the control group than in the experimental groups. In addition, the healing scores were statistically higher in the control and the Gr-MA + HyA groups. Comparisons of the control, graft, and HyA groups indicated that the control group exhibited significantly less necrosis on the 7th day; however, on the 21st day, there were no statistically significant differences among the groups. There were no statistically significant differences among the groups in terms of the inflammation and fibrosis levels on the 7th or 21st days. Conclusion: Within the limitations of this study, the application of HyA alone and the addition of HyA to Gr-MA did not improve bone regeneration in rat tibial defects.en_US
dc.description.sponsorshipIstanbul University Research Foundation [49881]; Istanbul, Turkeyen_US
dc.description.sponsorshipThis research was funded by Istanbul University Research Foundation with a Grant Number 49881, Istanbul, Turkeyen_US
dc.identifier.doi10.17826/cumj.669187
dc.identifier.endpage532en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue2en_US
dc.identifier.startpage526en_US
dc.identifier.trdizinid384855en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.669187
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/384855
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6909
dc.identifier.volume45en_US
dc.identifier.wosWOS:000537976000018en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHyaluronic aciden_US
dc.subjectbone graftingen_US
dc.subjectbone regenerationen_US
dc.subjectbone formationen_US
dc.subjectratsen_US
dc.titleEffects of hyaluronic acid and gamma-radiated mineralized allografts on the healing of rat tibial defectsen_US
dc.typeArticleen_US

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