Crocin, the compound of the dried stigma of Crocus sativus L (saffron), restores doxorubicin-induced disturbances in kidney functioning, oxidative stress, inflammation, renal tissue morphology and TGF-? signalling pathways

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridCetinavci, Dilan/0000-0002-4148-7711
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorCetinavci, Dilan
dc.contributor.authorAbdulkareem Aljumaily, Sara Asaad
dc.contributor.authorElbe, Hulya
dc.contributor.authorCengil, Osman
dc.contributor.authorBicer, Yasemin
dc.date.accessioned2024-09-29T16:02:53Z
dc.date.available2024-09-29T16:02:53Z
dc.date.issued2024
dc.departmentKarabük Üniversitesien_US
dc.description.abstractDoxorubicin (Dox), an anthracycline antibiotic, is a chemotherapeutic drug for several cancer treatments. However, its clinical usage has been restricted because of severe side effects, including nephrotoxicity. This study aimed to demonstrate the possible nephroprotective effects of crocin (Cr) against Dox-induced oxidative stress, renal inflammation, renal morphology and transforming growth factor-beta (TGF-beta) signalling pathways in Dox-exposed rats. Hence, the rats were injected for 15 d consecutively with saline, six different injections of Dox until the cumulative dose reached 12 mg/kg., daily Cr (40 mg/kg), and Dox + Cr combination. Cr increased the activities of superoxide dismutase (SOD) and catalase (CAT), GSH content and suppressed inflammation and oxidative stress in Dox-exposed rats. Our results were confirmed by immunohistochemical findings that Cr treatment ameliorates the expressions of IL1 beta and TGF-beta in Dox-induced nephrotoxicity. Conclusionally, Cr exhibits adequate nephroprotective effects against Dox-induced nephrotoxicity on rat kidney architecture and tissue function by stabilising cellular redox homeostasis, reducing renal fibrosis and suppressing inflammation. [GRAPHICS] .en_US
dc.identifier.doi10.1080/14786419.2024.2344180
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.pmid38662441en_US
dc.identifier.scopus2-s2.0-85191231171en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/14786419.2024.2344180
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5773
dc.identifier.wosWOS:001208261200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNatural Product Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectcrocinen_US
dc.subjectnephrotoxicityen_US
dc.subjectoxidative stressen_US
dc.subjectIL1 betaen_US
dc.subjectTGF-betaen_US
dc.titleCrocin, the compound of the dried stigma of Crocus sativus L (saffron), restores doxorubicin-induced disturbances in kidney functioning, oxidative stress, inflammation, renal tissue morphology and TGF-? signalling pathwaysen_US
dc.typeArticleen_US

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