Hepatoprotective effects of crocin on biochemical and histopathological alterations following acrylamide-induced liver injury in Wistar rats

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorGedik, Sema
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorGul, Mehmet
dc.contributor.authorYigitcan, Birgul
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorAltinoz, Eyup
dc.date.accessioned2024-09-29T15:55:04Z
dc.date.available2024-09-29T15:55:04Z
dc.date.issued2017
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe objective of the present study is the treatment of oxidative damage caused by acrylamide induced oxidative stress in rats with the administration of a strong antioxidant, namely crocin. High acrylamide (AA) levels have genotoxic, carcinogenic and neurotoxic effects on living organisms. In the present study, 40 Wistar rats were randomly divided into four equal groups. These groups were control, acrylamide (25 mg/kg), crocin (50 mg/kg), acrylamide + crocin (25 mg/kg acrylamide and 50 mg/kg crocin) groups. At the end of the application, biochemical and histological variations were examined in liver and blood samples. It was observed that acrylamide administration significantly decreased liver GSH and TAS levels when compared to the control group. On the contrary, it was also observed that AST, ALT, ALP, SOD and CAT activities and TOS and MDA levels increased as a result of acrylamide administration. Histopathological examinations demonstrated inflammatory cell infiltration, hepatocellular necrosis and hemorrhage areas in AA group liver sections. Furthermore, intracytoplasmic vacuolization was detected in hepatocytes. After crocin treatment, it was observed that GSH and TAS levels increased while AST, ALT, ALP, SOD and CAT activities and TOS and MDA levels decreased. Significant decreases were observed in inflammatory cell infiltration and vascular congestion in liver sections and intracytoplasmic vacuolization in hepatocytes after the crocin treatment, while no hepatocellular necrosis and hemorrhages were observed. In the present study, it was demonstrated that crocin treatment removed acrylamide induced liver damage due to the strong antioxidant properties of crocin.en_US
dc.description.sponsorshipKarabuk University Scientific Research Fund [KBU-BAP-15/2-YL-010]en_US
dc.description.sponsorshipThe present study was sponsored by Karabuk University Scientific Research Fund (KBU-BAP-15/2-YL-010)en_US
dc.identifier.doi10.1016/j.biopha.2017.08.139
dc.identifier.endpage770en_US
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid28892787en_US
dc.identifier.scopus2-s2.0-85028918484en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage764en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2017.08.139
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4436
dc.identifier.volume95en_US
dc.identifier.wosWOS:000417744400089en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofBiomedicine & Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylamideen_US
dc.subjectCrocinen_US
dc.subjectOxidative stressen_US
dc.subjectHepatotoxicityen_US
dc.titleHepatoprotective effects of crocin on biochemical and histopathological alterations following acrylamide-induced liver injury in Wistar ratsen_US
dc.typeArticleen_US

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