The Rate of Change in Alcohol Misuse Across Adolescence is Heritable

Basit Öğe Kaydı
dc.authoridHickman, Matthew/0000-0001-9864-459X
dc.authoridEdwards, Alexis/0000-0002-4006-9710
dc.authoridWolen, Aaron/0000-0003-2542-2202
dc.authoridHeron, Jon/0000-0001-6199-5644
dc.contributor.authorEdwards, Alexis C.
dc.contributor.authorHeron, Jon
dc.contributor.authorVladimirov, Vladimir
dc.contributor.authorWolen, Aaron R.
dc.contributor.authorAdkins, Daniel E.
dc.contributor.authorAliev, Fazil
dc.contributor.authorHickman, Matthew
dc.date.accessioned2024-09-29T16:04:32Z
dc.date.available2024-09-29T16:04:32Z
dc.date.issued2017
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: Alcohol use typically begins during adolescence and escalates into young adulthood. This represents an important period for the establishment of alcohol use and misuse patterns, which can have psychosocial and medical consequences. Although changes in alcohol use during this time have been phenotypically characterized, their genetic nature is poorly understood. Methods: Participants of the Avon Longitudinal Study of Parents and Children completed the Alcohol Use Disorders Identification Test (AUDIT) 4 times from age 16 to 20. We used Mplus to construct a growth model characterizing changes in AUDIT scores across time (N = 4,545, where data were available for at least 2 time points). The slope of the model was used as the phenotype in a genomewide association study (N = 3,380), followed by secondary genetic analyses. Results: No individual marker met genomewide significance criteria. Top markers mapped to biologically plausible candidate genes. The slope term was moderately heritable (h(SNP)(2) = 0.26, p = 0.009), and replication attempts using a meta-analysis of independent samples provided support for implicated variants at the aggregate level. Nominally significant (p < 0.00001) markers mapped to putatively active genomic regions in brain tissue more frequently than expected by chance. Conclusions: These results build on prior studies by demonstrating that common genetic variation impacts alcohol misuse trajectories. Influential loci map to genes that merit additional research, as well as to intergenic regions with regulatory functions in the central nervous system. These findings underscore the complex biological nature of alcohol misuse across development.en_US
dc.description.sponsorshipWellcome Trust [092731]; National Institutes of Health [AA021399, AA018333, 1P50AA022537, R21AA022749-01, UL1TR000058, R37AA011408]; MRC; ESRC [MR/L022206/1, ES/L015471/1]; ESRC [ES/L015471/1] Funding Source: UKRI; MRC [MR/L022206/1, MR/K023233/1, G0800612, G0802736] Funding Source: UKRIen_US
dc.description.sponsorshipWe are grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, and nurses. The U.K. Medical Research Council and the Wellcome Trust (Grant ref: 092731) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors, and ACE will serve as guarantor for the contents of this article. This research was specifically funded by the National Institutes of Health (AA021399, AA018333, 1P50AA022537, R21AA022749-01, UL1TR000058, and R37AA011408). We acknowledge additional support from MRC and ESRC (MR/L022206/1 & ES/L015471/1).en_US
dc.identifier.doi10.1111/acer.13262
dc.identifier.endpage64en_US
dc.identifier.issn2993-7175
dc.identifier.issue1en_US
dc.identifier.pmid27892595en_US
dc.identifier.scopus2-s2.0-85006154213en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.1111/acer.13262
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6193
dc.identifier.volume41en_US
dc.identifier.wosWOS:000393890700007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAlcohol-Clinical and Experimental Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectALSPACen_US
dc.subjectAlcohol Problemsen_US
dc.subjectGenetic Influencesen_US
dc.subjectHeritabilityen_US
dc.subjectLongitudinal Modelen_US
dc.titleThe Rate of Change in Alcohol Misuse Across Adolescence is Heritableen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu