Investigation of DNA Binding Activities of Peripherally 2,10,16,24-Tetrakis Dimethyl 5-(Phenoxy)-Isophthalate-Substituted Ni(II) Phthalocyanine Complex

Basit Öğe Kaydı
dc.contributor.authorArslantas, Ali
dc.contributor.authorAgirtas, Mehmet Salih
dc.date.accessioned2024-09-29T15:50:50Z
dc.date.available2024-09-29T15:50:50Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPeripherally 2, 10, 16, 24-tetrakis dimethyl 5-(phenoxy)-isophthalate-substituted Ni(II) phthalocyanine compound (Pc7) was previously synthesized and characterized. In this work, calf thymus DNA was used to specify DNA binding activities of Ni(II) phthalocyanine compound. DNA binding properties of Pc7 were studied using absorption titration, fluorescense spectroscopy, thermal melting temperature study, cyclic voltametry in a Tris-HCl buffer solution. The results indicated that Pc7 can bind to CT-DNA molecule through partial intercalation binding mechanisms. In addition to above methods, agarose gel electrophoresis and viscosity measurement were also conducted to confirm DNA binding activities activities of Pc7. The results of these methods indicated that Ni(II) phthalocyanine compound adheres to CT-DNA partial intercalative binding mode. These results confirm that Ni(II) phthalocyanine compound may become potential therapeutic agent for cancerous cells due to its DNA binding features.en_US
dc.description.sponsorshipCommission of Scientific Research Projects of Karabuk Universityen_US
dc.description.sponsorshipThis work was supported by the Commission of Scientific Research Projects of Karabuk University.en_US
dc.identifier.doi10.1002/slct.201800572
dc.identifier.endpage3160en_US
dc.identifier.issn2365-6549
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85044481754en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3155en_US
dc.identifier.urihttps://doi.org/10.1002/slct.201800572
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3747
dc.identifier.volume3en_US
dc.identifier.wosWOS:000428379500037en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistryselecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAbsorption titrationen_US
dc.subjectDNA bindingen_US
dc.subjectGel electrophoresisen_US
dc.subjectMelting pointen_US
dc.subjectPhthalocyaninesen_US
dc.titleInvestigation of DNA Binding Activities of Peripherally 2,10,16,24-Tetrakis Dimethyl 5-(Phenoxy)-Isophthalate-Substituted Ni(II) Phthalocyanine Complexen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu