The examination of the nephroprotective effect of montelukast sodium and N-acetylcysteine in renal ischemia with dimercaptosuccinic acid imaging in a placebo-controlled rat model

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dc.authoridkarakan, tolga/0000-0002-6694-8369
dc.authoridHURI, Emre/0000-0001-5563-4527
dc.authoridOzcan, Serkan/0000-0002-2459-139X
dc.contributor.authorAydin, Arif
dc.contributor.authorSunay, Mehmet Melih
dc.contributor.authorKarakan, Tolga
dc.contributor.authorOzcan, Serkan
dc.contributor.authorHascicek, Ahmet Metin
dc.contributor.authorYardimci, Ibrahim
dc.contributor.authorSurer, Hatice
dc.date.accessioned2024-09-29T16:06:24Z
dc.date.available2024-09-29T16:06:24Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPurpose: To determine the nephroprotective effect of NAC and Montelukast Sodium administration against the development of renal damage associated with long warm renal ischemia. Methods: Twenty-seven rats were randomly divided into 3 study groups, which received NAC, montelukast and placebo, and 3 rats were included in the sham-treated control group. Medications were given 3 days before the procedure. DMSA renal scintigraphy was performed before and after surgery. The right renal pedicle was occluded for 45 min to induce ischemia and then subjected to reperfusion for 6 h (I/R groups). Results: On pathological examination, the mean pathological scores of the montelukast and NAC groups were significantly lower than those of the placebo group. (p <0.05). In biochemical examination, significant differences were found in all parameter levels between the placebo group and the montelukast and NAC groups. (p <0.05) When postoperative DMSA renal scintigraphy measurements and renal function levels were compared, significant differences were found between the montelukast and NAC groups and the placebo and sham groups. Conclusion: The administration of NAC and montelukast sodium was seen to have a nephroprotective effect against the development of renal damage associated with warm renal ischemia.en_US
dc.identifier.doi10.1590/s0102-865020200090000005
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue9en_US
dc.identifier.pmid33084735en_US
dc.identifier.scopus2-s2.0-85092564508en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1590/s0102-865020200090000005
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6816
dc.identifier.volume35en_US
dc.identifier.wosWOS:000580974400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetylcysteineen_US
dc.subjectOxidative Stressen_US
dc.subjectReperfusion Injuryen_US
dc.subjectKidneyen_US
dc.subjectRatsen_US
dc.titleThe examination of the nephroprotective effect of montelukast sodium and N-acetylcysteine in renal ischemia with dimercaptosuccinic acid imaging in a placebo-controlled rat modelen_US
dc.typeArticleen_US

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