Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults

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dc.authoridEdenberg, Howard/0000-0003-0344-9690
dc.authoridNurnberger, John/0000-0002-7674-1767
dc.authoridLong, Elizabeth/0000-0001-9947-8132
dc.contributor.authorLong, Elizabeth C.
dc.contributor.authorAliev, Fazil
dc.contributor.authorWang, Jen-Chyong
dc.contributor.authorEdenberg, Howard J.
dc.contributor.authorNurnberger, John, Jr.
dc.contributor.authorHesselbrock, Victor
dc.contributor.authorPorjesz, Bernice
dc.date.accessioned2024-09-29T16:06:17Z
dc.date.available2024-09-29T16:06:17Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: The gene GRM8, a metabotropic glutamate receptor, has emerged as a gene of interest for its possible role in the development of alcohol dependence, with evidence of association with an electrophysiological endophenotype and level of response to alcohol as well as suggestive evidence of association with alcohol dependence. Method: The present study further investigated the association between GRM8 and alcohol dependence symptom counts among young adults using a new sample of individuals collected as part of the prospective sample (ages 18-26 years; N = 842) from the Collaborative Study on the Genetics of Alcoholism (COGA). Results: Two single-nucleotide polymorphisms were significantly associated with alcohol dependence in European Americans using the Nyholt corrected p value of .007: rs886003 (beta = -.212, p =.0002) and rs17862325 (beta = -.234, p < .0001), but not in African Americans, likely because of the lower power to detect association in this group. Conclusions: These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence.en_US
dc.description.sponsorshipNational Institutes of Health (NIH) from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) [U10AA008401]; National Institute on Drug Abuse (NIDA); [K02AA018755]en_US
dc.description.sponsorshipThis research was supported by National Institutes of Health (NIH) Grant U10AA008401 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA). This work was also funded by K02AA018755 (to Danielle M. Dick).en_US
dc.identifier.doi10.15288/jsad.2015.76.414
dc.identifier.endpage418en_US
dc.identifier.issn1937-1888
dc.identifier.issn1938-4114
dc.identifier.issue3en_US
dc.identifier.pmid25978827en_US
dc.identifier.scopus2-s2.0-84929427907en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage414en_US
dc.identifier.urihttps://doi.org/10.15288/jsad.2015.76.414
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6737
dc.identifier.volume76en_US
dc.identifier.wosWOS:000354755100009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAlcohol Res Documentation Inc Cent Alcohol Stud Rutgers Univen_US
dc.relation.ispartofJournal of Studies On Alcohol and Drugsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSingle-Nucleotide Polymorphismsen_US
dc.subjectLinkageen_US
dc.subjectFamilyen_US
dc.subjectRisken_US
dc.titleFurther Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adultsen_US
dc.typeArticleen_US

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