Neuroprotective efficacy of luteolin on a 900-MHz electromagnetic field-induced cerebellar alteration in adult male rat

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dc.contributor.authorYahyazadeh, Ahmad
dc.contributor.authorAltunkaynak, Berrin Zuhal
dc.date.accessioned2024-09-29T15:55:04Z
dc.date.available2024-09-29T15:55:04Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe adverse health consequences of exposure to electromagnetic field emitted from cell phone has recently raised public concerns worldwide. Also, the Global System for Mobile Communications (GSM) standard that operates in 900 MHz frequency is the most popular. Therefore, we aimed to investigate the adverse effect of exposure to 900 MHz EMF (1 h/day) on the cerebella of 12-week-old rats. We also evaluated the protective activity of luteolin (20 mu g/kg/day) against possible biological change in the cerebellar tissues exposed to EMF. Twenty-four male wistar albino rats were randomly assigned into four group of six rats: Control, EMF, EMF + luteolin, luteolin. Serological and biochemical analyses, as well as histopathological examination were performed on all cerebellar samples. We found that SOD (superoxide dismutase) level was significantly increased in the EMF group compared to the control group (p < 0.05). To the contrary, decreased SOD activity was detected in the EMF + luteolin group compared to control group (p < 0.05). The total number of Purkinje and granular cells was significantly decreased in the EMF group compared to the control group (p < 0.05). In the EMF + luteolin group, the total number of Purkinje and granular cells was significantly higher than the EMF group (p < 0.05). Histopathological evaluation also showed destructive damage to the architectures of cerebellar tissues. Our results suggest that exposure to EMF may cause cellular damage to the rat cerebellum. Further, the improvement of cerebellar damage may have resulted from antioxidant efficacy of luteolin by alleviating oxidative stress.en_US
dc.description.sponsorshipProject Management Office, Turkeyen_US
dc.description.sponsorshipWe would like to thank Dr. Rogayyeh Yahyazadeh and Fariba Javadzadeh for their scientific guidance. This work was supported by the Project Management Office, Turkey.en_US
dc.identifier.doi10.1016/j.brainres.2020.146919
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid32485174en_US
dc.identifier.scopus2-s2.0-85085570151en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2020.146919
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4443
dc.identifier.volume1744en_US
dc.identifier.wosWOS:000541249900005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBrain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerebellumen_US
dc.subjectElectromagnetic fielden_US
dc.subjectLuteolinen_US
dc.subjectRaten_US
dc.subjectSuperoxide dismutaseen_US
dc.titleNeuroprotective efficacy of luteolin on a 900-MHz electromagnetic field-induced cerebellar alteration in adult male raten_US
dc.typeArticleen_US

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