Strontium and fluorine co-doped biphasic calcium phosphate: characterization and in vitro cytocompatibility analysis

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dc.authoridPOURREZA, ELMIRA/0000-0002-7290-5680
dc.authoridTezcaner, Aysen/0000-0003-4292-5856
dc.authoridEvis, Zafer/0000-0002-7518-8162
dc.authoridAlshemary, Ammar Z/0000-0001-5367-1869
dc.contributor.authorPourreza, Elmira
dc.contributor.authorAlshemary, Ammar Z.
dc.contributor.authorYilmaz, Bengi
dc.contributor.authorRad, Reza Moonesi
dc.contributor.authorTezcaner, Aysen
dc.contributor.authorEvis, Zafer
dc.date.accessioned2024-09-29T16:03:05Z
dc.date.available2024-09-29T16:03:05Z
dc.date.issued2017
dc.departmentKarabük Üniversitesien_US
dc.description.abstractStrontium (Sr2+) and fluoride (F-) ions are known to play an important role in bone and tooth metabolism. In this work, we prepare biphasic calcium phosphate (BCP) bioceramics co-doped with different fractions of Sr2+ and F- ions to investigate the impact of dopant on the crystal structure and biological properties of BCP bioceramics. The materials were successfully synthesized using a wet precipitation method, followed by sintering at 1100 degrees C for 1 h. The sintered materials were characterized using x-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and field emission scanning electron microscopy (FESEM). XRD analysis revealed that the BCP bioceramics were composed of hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP), along with calcium oxide (CaO) as impurity. Furthermore, the percentage of beta-TCP tended to increase with an increase in the Sr2+ ion concentration. The lattice parameters of HA phase expanded along with incorporation of Sr2+ and F- ions. The morphology of the yielding materials demonstrated that the incorporation of Sr2+ and F- ions caused a decrease in the grain size. The Vickers hardness (HV) test showed that hardness values increased with increasing Sr2+ concentrations. In vitro cell culture tests were performed with human osteogenic sarcoma (Saos-2) cell line. Saos-2 cells attached and proliferated faster on Sr/F-BCP materials compared to pure BCP, showing that Sr/F-BCP materials were cytocompatible.en_US
dc.identifier.doi10.1088/2057-1976/aa768c
dc.identifier.issn2057-1976
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85029498188en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1088/2057-1976/aa768c
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5893
dc.identifier.volume3en_US
dc.identifier.wosWOS:000411076800005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIop Publishing Ltden_US
dc.relation.ispartofBiomedical Physics & Engineering Expressen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiphasic calcium phosphateen_US
dc.subjectco-dopingen_US
dc.subjectstrontiumen_US
dc.subjectfluorineen_US
dc.subjectcharacterizationen_US
dc.subjecthardnessen_US
dc.subjectcytocompatibilityen_US
dc.titleStrontium and fluorine co-doped biphasic calcium phosphate: characterization and in vitro cytocompatibility analysisen_US
dc.typeArticleen_US

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