Blood and faecal lead levels in children with various functional gastrointestinal disorders

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dc.contributor.authorSevinc, Nergiz
dc.contributor.authorBilici, Namik
dc.contributor.authorSevinc, Eylem
dc.contributor.authorDogan, Erkan
dc.date.accessioned2024-09-29T15:54:56Z
dc.date.available2024-09-29T15:54:56Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIntroduction: To investigate the blood lead levels (BLLs) and faecal lead levels (FLLs) in children with various functional gastrointestinal disorders (FGIDs) and compare them with controls. Patients and methods: One hundred and 2 children with FGIDs defined by the Rome IV criteria, aged 4-18 years, and one hundred and 2 sex matched healthy children were enrolled in the study. Children with FGIDs were divided into 3 subgroups as functional constipation (FC) (n = 36), functional abdominal pain (FAP) (n = 36) and functional nausea (FN) (n = 30). The lead levels were measured using atomic absorption spectrometer. Results: The median BLLs in the FGIDs group was significantly higher than in controls (5.12 and 1.77 mu g/dL, respectively). The BLLs were above 5 mu g/dL in 51,9% of children with FGIDs. There was statistically significant difference in BLLs between FC subgroup and the other subgroups (FAP and FN) (P=.003, P<.001 respectively). The FLLs in the FGIDs group was significantly higher than in controls (28.08 and 0.01 mu g/g, respectively). There was no significant difference in FLLs between FC subgroup and the other subgroups (P=.992, P=.989 respectively). No significant relation found between BLLs and FLLs of the FGIDs group (P =.123). Conclusion: This study revealed that children with FGIDs had higher BLLs and FLLs than controls and also more than half of children with FGIDs had BLLs >= 5 mu g/dL which is toxic level. These results might revive the question of whether or not clinician need to evaluate routine BLLs in children with FGIDs. (C) 2020 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U.en_US
dc.identifier.doi10.1016/j.anpedi.2020.07.033
dc.identifier.endpage42en_US
dc.identifier.issn1695-4033
dc.identifier.issn1695-9531
dc.identifier.issue1en_US
dc.identifier.pmid33441262en_US
dc.identifier.scopus2-s2.0-85099228237en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage35en_US
dc.identifier.urihttps://doi.org/10.1016/j.anpedi.2020.07.033
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4370
dc.identifier.volume96en_US
dc.identifier.wosWOS:000744132600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isospen_US
dc.publisherEdiciones Doyma S Aen_US
dc.relation.ispartofAnales De Pediatriaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFunctional gastrointestinal disordersen_US
dc.subjectBlood lead levelen_US
dc.subjectFaecal lead levelen_US
dc.subjectChildrenen_US
dc.titleBlood and faecal lead levels in children with various functional gastrointestinal disordersen_US
dc.typeArticleen_US

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