Linalool exhibits therapeutic and protective effects in a rat model of doxorubicin-induced kidney injury by modulating oxidative stress

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridONER, ZULAL/0000-0003-0459-1015
dc.authoridUremis, Nuray/0000-0002-3958-4352
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorOner, Zulal
dc.contributor.authorElbe, Hulya
dc.contributor.authorUremis, Nuray
dc.contributor.authorUremis, Muhammed
dc.date.accessioned2024-09-29T16:01:15Z
dc.date.available2024-09-29T16:01:15Z
dc.date.issued2022
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the therapeutic and protective effects of linalool against doxorubicin (DOX)-induced kidney injury. Forty-eight Wistar rats were divided into 8 groups as follows; Control, DOX [20 mg/kg, intraperitoneal (ip) single dose DOX], linalool (LIN50 and LIN100; 50 mg/kg and 100 mg/kg linalool via ip for 5 days, respectively), DOX + LIN50 and DOX + LIN100 (20 mg/kg single dose of DOX via ip on first day and 50 mg/kg and 100 mg/kg linalool via ip, respectively), LIN50 + DOX and LIN100 + DOX (50 mg/kg and 100 mg/kg linalool via ip for 5 days, respectively and 20 mg/kg single dose of DOX via ip on fifth day). Doxorubicin led to a significant increase in the level of malondialdehyde (MDA) in the kidney, whereas superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) levels decreased remarkably when compared with control. On the other hand, LIN supplementation before and after DOX treatment led to a significant decrease in MDA and also increases in SOD, CAT and GSH levels. DOX caused significant increases in the levels of blood urea nitrogen (BUN) and creatinine (Cr) levels in the plasma, while LIN supplementation as a therapeutic and preventive agent led to significant decreases in BUN and Cr levels. The current study demonstrated that LIN supplementation after or before DOX treatment can led to therapeutic and preventive effects against DOX-induced renal damage.en_US
dc.identifier.doi10.1080/01480545.2021.1894751
dc.identifier.endpage2030en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue5en_US
dc.identifier.pmid33682561en_US
dc.identifier.scopus2-s2.0-85102183241en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2024en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2021.1894751
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5620
dc.identifier.volume45en_US
dc.identifier.wosWOS:000626326600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectlinaloolen_US
dc.subjectkidney damageen_US
dc.subjectrenal dysfunctionen_US
dc.subjectoxidative stressen_US
dc.titleLinalool exhibits therapeutic and protective effects in a rat model of doxorubicin-induced kidney injury by modulating oxidative stressen_US
dc.typeArticleen_US

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