Fragmented QRS is associated with subclinical left ventricular dysfunction in patients with chronic kidney disease

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dc.contributor.authorAdar, A.
dc.contributor.authorKiris, A.
dc.contributor.authorUlusoy, S.
dc.contributor.authorÖzkan, G.
dc.contributor.authorBektas, H.
dc.contributor.authorOkutucu, S.
dc.contributor.authorOnalan, O.
dc.date.accessioned2024-09-29T16:16:26Z
dc.date.available2024-09-29T16:16:26Z
dc.date.issued2014
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: We aimed to investigate the association of fragmented QRS (fQRS) with subclinical left ventricular (LV) dysfunction in patients with chronic kidney disease (CKD). Methods and results: Patients with CKD who had a normal LV ejection fraction (? 50%) were enrolled. The tissue Doppler-derived Tei index was measured for all patients. A Tei index of ? 0.5 was considered abnormal. Subclinical LV dysfunction was defined as the presence of an abnormal Tei index in the absence of impaired LV ejection fraction (< 50%). The fQRS was defined as the presence of an additional R wave (R') or notching of R or S wave or the presence of fragmentation in two contiguous ECG leads. The study group consisted of 82 patients (45 male, mean age 54 ± 14 years). Overall, prevalence of fQRS was 60% among CKD patients who had a preserved LV ejection fraction. Of these, 52 (63%) had an abnormal (? 0.5) and 30 (37%) a normal Tei index (< 0.5). The prevalence of fQRS was significantly higher in patients with an abnormal Tei index than in patients with a normal Tei index (71% vs. 40%, P = 0.006). Patients with an abnormal Tei index had a lower E/A ratio as compared to patients with a normal Tei index (P = 0.03). Groups were similar with respect to all other variables. In multivariate logistic regression analysis, the presence of fQRS was independently associated (OR 3.52, 95% CI 1.28-9.64) with the presence of an abnormal Tei index after adjustment for potential confounders. Conclusion: Fragmented QRS is independently associated with subclinical LV dysfunction in patients with CKD and normal ejection fraction.en_US
dc.identifier.doi10.2143/AC.69.4.3036654
dc.identifier.endpage390en_US
dc.identifier.issn0001-5385
dc.identifier.issue4en_US
dc.identifier.pmid25181913en_US
dc.identifier.scopus2-s2.0-84906096767en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage385en_US
dc.identifier.urihttps://doi.org/10.2143/AC.69.4.3036654
dc.identifier.urihttps://hdl.handle.net/20.500.14619/9070
dc.identifier.volume69en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cardiologicaen_US
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic kidney diseaseen_US
dc.subjectFragmented QRSen_US
dc.subjectLeft ventricular dysfunctionen_US
dc.titleFragmented QRS is associated with subclinical left ventricular dysfunction in patients with chronic kidney diseaseen_US
dc.typeArticleen_US

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