Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation

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dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.authoriddikmen, nursel/0000-0002-5923-400X
dc.authoridIsler, Cafer Tayer/0000-0002-1910-8316
dc.authoridKUZU, Muslum/0000-0002-1375-7673
dc.authoridTURK, ERDINC/0000-0003-1735-1774
dc.authoridGOKCEK, ISHAK/0000-0002-0590-6405
dc.authoridEtyemez, Muhammed/0000-0003-0497-1878
dc.contributor.authorCellat, Mustafa
dc.contributor.authorKuzu, Muslum
dc.contributor.authorIsler, Cafer Tayer
dc.contributor.authorEtyemez, Muhammed
dc.contributor.authorDikmen, Nursel
dc.contributor.authorUyar, Ahmet
dc.contributor.authorGokcek, Ishak
dc.date.accessioned2024-09-29T15:51:01Z
dc.date.available2024-09-29T15:51:01Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractAsthma is an inflammatory disease that affects many people around the world, especially persons at paediatric age group. The effectiveness of tyrosol, a natural phenolic compound, was examined in the asthma model induced by ovalbumin (OVA). For this purpose, four groups, each consisting of eight rats, were arranged. For 21 days, physiological saline solution was treated to the control group and OVA was treated to the groups of OVA, OVA + dexamethasone (Dexa) and OVA + tyrosol groups, intraperitoneally and through inhalation. Additionally, 0.25 mg/kg Dexa was treated to the OVA + Dexa group and 20 mg/kg tyrosol to the OVA + tyrosol group by oral gavage. Serum, blood, bronchoalveolar lavage fluid (BALF) and lung tissues of the rats were examined. It was observed that MDA level decreased, GSH level and GPx activity increased, and there was no change in CAT activity in lung tissues of the tyrosol treatment groups. It was also observed that NF-kappa B, TNF-alpha, IL-4, IL-5, IL-13, IFN-gamma and IgE levels decreased compared to the OVA group in lung tissue and serum samples except for serum NF-kappa B and IL-4. However, no effect on IL-1 beta level was observed. In addition, it was determined that tyrosol treatment increased the IL-10 level on both tissue samples. The results of the histopathological investigation of lung tissue showed that tyrosol significantly ameliorated OVA-induced histopathological lesions. Additionally, PAS staining showed that mucus hypersecretion was significantly reduced with the use of tyrosol. In addition, it was determined that the number of eosinophils decreased significantly in blood and BALF samples. The obtained results showed that tyrosol possessed antioxidant and anti-inflammatory features on OVA-induced rats and preserved tissue architecture.en_US
dc.description.sponsorshipUnit of Scientific Research Projects of Mustafa Kemal University [19]en_US
dc.description.sponsorshipThis research was supported by the Unit of Scientific Research Projects of Mustafa Kemal University (Project number 19.M.041).en_US
dc.identifier.doi10.1007/s00210-021-02117-y
dc.identifier.endpage2075en_US
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue10en_US
dc.identifier.pmid34287677en_US
dc.identifier.scopus2-s2.0-85110727203en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2061en_US
dc.identifier.urihttps://doi.org/10.1007/s00210-021-02117-y
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3839
dc.identifier.volume394en_US
dc.identifier.wosWOS:000675297100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNaunyn-Schmiedebergs Archives of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsthmaen_US
dc.subjectTyrosolen_US
dc.subjectAntioxidanten_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAnti-allergicen_US
dc.titleTyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammationen_US
dc.typeArticleen_US

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