Effects of the Ischemic Preconditioning on Anastomotic Healing in Laparoscopic Colon Operations

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dc.contributor.authorGurdal, Sibel O.
dc.contributor.authorCelik, Atilla
dc.contributor.authorCelik, Aysun S.
dc.contributor.authorGuzel, Savas
dc.contributor.authorMete, Rafet
dc.contributor.authorSahin, Onder
dc.contributor.authorSoybir, Gursel R.
dc.date.accessioned2024-09-29T16:03:12Z
dc.date.available2024-09-29T16:03:12Z
dc.date.issued2013
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: Previous experimental studies have repeatedly demonstrated the potential protective effect of remote ischemic preconditioning (IPC) on colon anastomosis. The purpose of this experimental study was to investigate the possible positive effects of IPC by interval insufflations in laparoscopic colon operations.Methods: Thirty Wistar-albino rats were randomized into 3 groups. Colonic transsection and anastomosis were performed in the control group. In the laparoscopic colon operation without IPC group, the intra-abdominal pressure was raised to 14 mm Hg for 60 minutes, and then laparotomy and colonic anastomosis were performed. In the IPC group, the intra-abdominal pressure was raised to 14 mm Hg for 5 minutes, followed by desufflation. Laparotomy and colonic anastomosis were performed exactly as in the non-IPC group. On the seventh postoperative day, all animals were killed, and blood and tissue samples were obtained. Anastomotic healing and inflammatory responses were determined by histopathologic examination and by measuring the anastomotic bursting pressure, tissue hydroxyproline level, and tissue and serum nitric oxide, malondialdehyde (MDA), and catalase activity levels. Differences with P-values of <0.05 were considered to be statistically significant.Results: Although the best anastomotic healing was detected in the control group, anastomotic healing was better in the IPC group than that in the non-IPC group. In terms of anastomotic bursting pressure, plasma MDA, serum catalase activity, and tissue nitric oxide levels, the IPC group was superior to the non-IPC group. No significant differences were found between the control and IPC groups, except in the plasma MDA levels.Conclusions: Use of IPC with colon anastomosis had positive effects on wound healing and may serve as a safe method to reduce the adverse effects of ischemia and wound healing in laparoscopic colon operations.en_US
dc.identifier.doi10.1097/SLE.0b013e31828e3be0
dc.identifier.endpage393en_US
dc.identifier.issn1530-4515
dc.identifier.issn1534-4908
dc.identifier.issue4en_US
dc.identifier.pmid23917594en_US
dc.identifier.scopus2-s2.0-84881650274en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage388en_US
dc.identifier.urihttps://doi.org/10.1097/SLE.0b013e31828e3be0
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5954
dc.identifier.volume23en_US
dc.identifier.wosWOS:000323216900013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofSurgical Laparoscopy Endoscopy & Percutaneous Techniquesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectlaparoscopic colon operationen_US
dc.subjectischemic preconditionen_US
dc.subjectcolonic anastomosis healingen_US
dc.titleEffects of the Ischemic Preconditioning on Anastomotic Healing in Laparoscopic Colon Operationsen_US
dc.typeArticleen_US

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