Permeability and fluid flow-induced wall shear stress in bone scaffolds with TPMS and lattice architectures: A CFD analysis

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dc.authoridONEL, SELIS/0000-0001-5184-0323
dc.authoridBlanquer, Sebastien/0000-0002-5366-6530
dc.authoridAli, Daver/0000-0002-8500-7820
dc.authoridMEHMET, OZALP/0009-0004-7202-1940
dc.contributor.authorAli, Davar
dc.contributor.authorOzalp, Mehmet
dc.contributor.authorBlanquer, Sebastien B. G.
dc.contributor.authorOnel, Selis
dc.date.accessioned2024-09-29T15:57:10Z
dc.date.available2024-09-29T15:57:10Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractFluid flow dynamics within porous scaffolds for tissue engineering play a critical role in the transport of fundamental materials to the cells and in controlling the biocompatibility of the scaffold. Properties such as permeability and fluid flow-induced wall shear stress characterize the biological behavior of the scaffolds. Bioactivity depends on the diffusion of oxygen and other nutritious elements through the porous medium and fluid flow-induced shear stress is known as the dominant mechanical stimulant of cell differentiation and proliferation within the scaffolds. In this study, eight different bone scaffold models with a constant porosity of 80% were designed computationally using the TPMS and lattice-based structures. We investigated the fluid flow within the scaffolds using CFD analysis. The results of the work showed that scaffold architecture has a significant impact on the permeability and that scaffold permeability can vary up to three times depending on the architecture. The scaffolds with the minimal variation in their channel size exhibited the highest permeability. We investigated the distribution statistics of wall shear stress on the walls of the scaffolds and showed that a correlation between the architecture of the scaffolds and the distribution statistics of wall shear stress did not exist. The outcomings of this work can be promising in designing better scaffolds in tissue engineering from a biological point of view. (C) 2019 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.euromechflu.2019.09.015
dc.identifier.endpage385en_US
dc.identifier.issn0997-7546
dc.identifier.issn1873-7390
dc.identifier.scopus2-s2.0-85073551692en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage376en_US
dc.identifier.urihttps://doi.org/10.1016/j.euromechflu.2019.09.015
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4635
dc.identifier.volume79en_US
dc.identifier.wosWOS:000503315100033en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Journal of Mechanics B-Fluidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone scaffoldsen_US
dc.subjectPermeabilityen_US
dc.subjectWall shear stressen_US
dc.subjectMinimal surface architecturesen_US
dc.subjectLattice-based architecturesen_US
dc.titlePermeability and fluid flow-induced wall shear stress in bone scaffolds with TPMS and lattice architectures: A CFD analysisen_US
dc.typeArticleen_US

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