Protective effects of ellagic acid against chemotherapy-induced hepatotoxicity

Basit Öğe Kaydı
dc.contributor.authorYalçin, A.
dc.contributor.authorKeles, H.
dc.contributor.authorKahraman, T.
dc.contributor.authorBozkurt, M.F.
dc.contributor.authorAydin, H.
dc.date.accessioned2024-09-29T16:16:27Z
dc.date.available2024-09-29T16:16:27Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractAim: Cyclophosphamide (CP) is a commonly used chemotherapeutic agent despite its toxic adverse effects, including hepatotoxicity. Ellagic acid (EA) is an antioxidant agent and exhibits free radical scavenging activities. In this experimental study, the effects of EA on CP-induced liver injury were investigated. Material and Methods: Twenty-four Sprague-Dawley rats (180-220 gr) were separated into four equal groups. A single dose of 150 mg/kg CP was given intraperitoneally to generate hepatotoxicity. Different doses (50 and 75 mg/kg) of EA were administered orally 20 minutes before, 4 and 8 hours after CP administration. The histopathological evaluation of kidney tissues and immunohistochemical evaluation for caspase-3 were conducted as well as the serum biochemical analyses. Results: CP treated group exhibited a significant increase in serum hepatic enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), compared to the control group. Similarly, the total triglycerides (TG) and very-low-density lipoprotein cholesterol (VLDL-C) levels increased significantly. Additionally, the high-density lipoprotein cholesterol (HDL-C) levels decreased, which was not significant, compared to the control group. At both EA doses, VLDL-C, AST, ALT levels decreased significantly while HDL-C level revealed a significant increase. 75 mg/kg EA treatment caused a non-significant elevation in total cholesterol (TC) concentration. Microscopic analysis showed a significant congestion, edema, degeneration and necrosis in the livers of CP administered group. However, edema, degeneration, and necrosis were significantly reduced in animals treated with EA-75. In addition, caspase-3 expression significantly decreased in EA-75 group. Conclusion: These results indicate the protective effects of EA in CP-induced hepatotoxicity in rats. © 2020, Duzce University Medical School. All rights reserved.en_US
dc.identifier.doi10.18678/dtfd.748816
dc.identifier.endpage130en_US
dc.identifier.issn1307-671X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85089830009en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage124en_US
dc.identifier.trdizinid385820en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.748816
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/385820
dc.identifier.urihttps://hdl.handle.net/20.500.14619/9086
dc.identifier.volume22en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDuzce Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCaspase-3en_US
dc.subjectCyclophosphamideen_US
dc.subjectEllagic aciden_US
dc.subjectHepatotoxicityen_US
dc.subjectLipidsen_US
dc.titleProtective effects of ellagic acid against chemotherapy-induced hepatotoxicityen_US
dc.title.alternativeKemoterapi kaynaklı hepatotoksisiteye karşı ellajik asitin koruyucu etkilerien_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu