Titanium dioxide-induced fibrotic liver model and the therapeutic effect of resveratrol by modulation of α-SMA and 8-oHdG expressions, oxidative stress, and inflammation
Küçük Resim Yok
Tarih
2025-01-18
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The research sought to assess the therapeutic impact of resveratrol by biochemical, immunohistochemical, and histopathological analyses in a TiO2-induced liver fibrosis model. Titanium dioxide (100 mg/kg body weight) was delivered for 15 days to induce liver fibrosis, either alone or in conjunction with resveratrol (30 mg/kg body weight) therapy for the same duration. Resveratrol has been identified as a crucial therapeutic drug that provides an alternative treatment method for TiO2-induced liver fibrosis by mitigating inflammation, oxidative stress, and the expressions of α-SMA and 8-OHdG. Resveratrol treatment mitigated TiO2-induced liver fibrosis by repairing hepatocellular injury and decreasing plasma AST, ALT, and ALP levels. Resveratrol improves the activity of superoxide dismutase (SOD) and catalase (CAT), crucial enzymes for antioxidant defense, and elevates glutathione peroxidase (GSH-Px) levels, so augmenting antioxidant function. Furthermore, resveratrol decreased hepatic inflammation (IL-6 and IL-1β) and oxidative stress markers. Furthermore, histological alterations and immunohistochemistry expression of α-SMA and 8-OhdG were reinstated after resveratrol administration in the TiO2-induced liver fibrosis model. Our research indicates that resveratrol administration effectively protects against liver fibrosis produced by TiO2.
Açıklama
This study was supported by Karabuk University Scientific Research Projects Coordination Unit as project number KBUEBAP-24-DS-001.
Bu çalışma Karabük Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü tarafından KBUEBAP-24-DS-001 proje numarasıyla desteklenmiştir.
Anahtar Kelimeler
8-OHdG, Inflammation, Liver fibrosis, Oxidative stress, Resveratrol, TiO2, α- SMA
Kaynak
Tissue and Cell
WoS Q Değeri
Q3
Scopus Q Değeri
Q4
Cilt
93
Sayı
Künye
Başak, F., Kuşat, T., Ersan, Y., & Kahraman, T. (2025). Titanium dioxide-induced fibrotic liver model and the therapeutic effect of resveratrol by modulation of α-SMA and 8-oHdG expressions, oxidative stress, and inflammation. Tissue & cell, 93, 102748. Advance online publication. https://doi.org/10.1016/j.tice.2025.102748
