Titanium dioxide-induced fibrotic liver model and the therapeutic effect of resveratrol by modulation of α-SMA and 8-oHdG expressions, oxidative stress, and inflammation

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dc.authoridhttps://orcid.org/0000-0002-9335-1103
dc.authoridhttps://orcid.org/0000-0001-7237-1562
dc.authoridhttps://orcid.org/0000-0002-0065-3656
dc.authoridhttps://orcid.org/0000-0003-4238-8528
dc.contributor.authorBaşak, Feyza
dc.contributor.authorKuşat, Tansu
dc.contributor.authorErsan, Yusuf
dc.contributor.authorKahraman, Tahir
dc.date.accessioned2025-02-26T11:54:18Z
dc.date.available2025-02-26T11:54:18Z
dc.date.issued2025-01-18
dc.departmentFakülteler, Tıp Fakültesi, Acil Tıp Bilimleri Bölümü
dc.descriptionThis study was supported by Karabuk University Scientific Research Projects Coordination Unit as project number KBUEBAP-24-DS-001. Bu çalışma Karabük Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü tarafından KBUEBAP-24-DS-001 proje numarasıyla desteklenmiştir.
dc.description.abstractThe research sought to assess the therapeutic impact of resveratrol by biochemical, immunohistochemical, and histopathological analyses in a TiO2-induced liver fibrosis model. Titanium dioxide (100 mg/kg body weight) was delivered for 15 days to induce liver fibrosis, either alone or in conjunction with resveratrol (30 mg/kg body weight) therapy for the same duration. Resveratrol has been identified as a crucial therapeutic drug that provides an alternative treatment method for TiO2-induced liver fibrosis by mitigating inflammation, oxidative stress, and the expressions of α-SMA and 8-OHdG. Resveratrol treatment mitigated TiO2-induced liver fibrosis by repairing hepatocellular injury and decreasing plasma AST, ALT, and ALP levels. Resveratrol improves the activity of superoxide dismutase (SOD) and catalase (CAT), crucial enzymes for antioxidant defense, and elevates glutathione peroxidase (GSH-Px) levels, so augmenting antioxidant function. Furthermore, resveratrol decreased hepatic inflammation (IL-6 and IL-1β) and oxidative stress markers. Furthermore, histological alterations and immunohistochemistry expression of α-SMA and 8-OhdG were reinstated after resveratrol administration in the TiO2-induced liver fibrosis model. Our research indicates that resveratrol administration effectively protects against liver fibrosis produced by TiO2.
dc.description.sponsorshipFunding agency Karabuk University Scientific Research Projects Coordination Unit Grant number KBUEBAP-24-DS-001
dc.identifier10.1016/j.tice.2025.102748
dc.identifier.citationBaşak, F., Kuşat, T., Ersan, Y., & Kahraman, T. (2025). Titanium dioxide-induced fibrotic liver model and the therapeutic effect of resveratrol by modulation of α-SMA and 8-oHdG expressions, oxidative stress, and inflammation. Tissue & cell, 93, 102748. Advance online publication. https://doi.org/10.1016/j.tice.2025.102748
dc.identifier.doi10.1016/j.tice.2025.102748
dc.identifier.issn0040-8166
dc.identifier.pmid39847895
dc.identifier.scopus2-s2.0-85215548264
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.1016/j.tice.2025.102748
dc.identifier.urihttps://hdl.handle.net/20.500.14619/15090
dc.identifier.volume93
dc.identifier.wosWOS:001408651400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofTissue and Cell
dc.relation.ispartofseriesTissue and Cell
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject8-OHdG
dc.subjectInflammation
dc.subjectLiver fibrosis
dc.subjectOxidative stress
dc.subjectResveratrol
dc.subjectTiO2
dc.subjectα- SMA
dc.titleTitanium dioxide-induced fibrotic liver model and the therapeutic effect of resveratrol by modulation of α-SMA and 8-oHdG expressions, oxidative stress, and inflammation
dc.typeArticle
oaire.citation.volume93

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