Crocin treatment exerts anti-inflammatory and anti-oxidative effects in liver tissue damage of pinealectomized diabetic rats

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridDEMIR, MEHMET/0000-0001-6990-3337
dc.contributor.authorKarayakali, Melike
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorElbe, Hulya
dc.contributor.authorKoca, Oguzhan
dc.contributor.authorOnal, Melike Ozgul
dc.contributor.authorBicer, Yasemin
dc.contributor.authorDemir, Mehmet
dc.date.accessioned2024-09-29T15:51:27Z
dc.date.available2024-09-29T15:51:27Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractDiabetes mellitus (DM) is a chronic metabolic disorder with an increasing global prevalence that leads to significant morbidity and mortality. The liver plays a vital role in glycemic regulation in physiological and pathological conditions such as DM. Free radical formation and inhibition of antioxidant defense systems play a role in the liver damage pathogenesis in diabetic patients The antioxidant, anti-diabetic, anti-inflammatory, and radical scavenging properties of crocin are known. This study was designed to determine the possible protective effects of crocin against liver tissue damage in pinealectomized diabetic rats. Sixty rats were divided into six groups: Control, Sham+streptozotocin (STZ), Pinealectomy (PINX), PINX+STZ, PINX+Crocin, and PINX+STZ+Crocin. PNX procedure was carried out on the first day of the experiment. Intraperitoneal (i.p.) injection of 50 mg/kg STZ was performed on the 30th day of the experiment to induce DM. Crocin (50 mg/kg; i.p.) was applied for 15 days after the pinealectomy procedure and induction of DM. Crocin decreased the markers (alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), interleukin-1 beta (IL-1 beta), and malondialdehyde (MDA)) of liver damage and increased antioxidant enzyme levels and tissue total antioxidant status. Histological results showed that the administration of crocin exhibited a protective effect against liver damage caused by STZ. These results indicate that crocin evidence protection against liver injury caused by STZ.en_US
dc.description.sponsorshipKarabuk University Scientific Research Fund [KBUBAP-21-YL-044]en_US
dc.description.sponsorshipThe present study received support from the Karabuk University Scientific Research Fund (KBUBAP-21-YL-044).en_US
dc.identifier.doi10.1007/s11356-023-25766-3
dc.identifier.endpage47684en_US
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.issue16en_US
dc.identifier.pmid36746856en_US
dc.identifier.scopus2-s2.0-85147568932en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage47670en_US
dc.identifier.urihttps://doi.org/10.1007/s11356-023-25766-3
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4082
dc.identifier.volume30en_US
dc.identifier.wosWOS:000950271400009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEnvironmental Science and Pollution Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrocinen_US
dc.subjectOxidative stressen_US
dc.subjectInflammationen_US
dc.subjectPinealectomyen_US
dc.subjectLiver damageen_US
dc.subjectRaten_US
dc.subjectDiabetes mellitusen_US
dc.titleCrocin treatment exerts anti-inflammatory and anti-oxidative effects in liver tissue damage of pinealectomized diabetic ratsen_US
dc.typeArticleen_US

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