Effects of glucagon as a neurohormone on the central nervous system and glucose homeostasis

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dc.contributor.authorTanbek, K.
dc.contributor.authorYilmaz, U.
dc.contributor.authorGul, S.
dc.contributor.authorKoç, A.
dc.contributor.authorGul, M.
dc.contributor.authorSandal, S.
dc.date.accessioned2024-09-29T16:16:22Z
dc.date.available2024-09-29T16:16:22Z
dc.date.issued2024
dc.departmentKarabük Üniversitesien_US
dc.description.abstractOBJECTIVE: This study aimed to elucidate the possible effects of the acute/ long-term infusion of glucagon in the brain as the regulatory role on the endocrine secretions of the pancreas. MATERIALS AND METHODS: Ninety male Wistar albino rats were divided as Control, artificial Cerebrospinal Fluid (aCSF) (120 min), Glucagon (120 min), pancreatic denervation (PD)+aCSF (120 min), PD+Glucagon (120 min), aCSF (7 days), Glucagon (7 days), PD+aCSF (7 days) and PD+Glucagon (7 days). Glucagon and solvent (aCSF) were administered after pancreatic denervation (PD) by Hamilton syringe and osmotic mini pump (1 µg/10 µl/min) in the third ventricle of the brain. RESULTS: Acute intracerebroventricular (icv) administration of glucagon resulted in an elevation of glucagon levels and a concurrent reduction in blood glucose levels. Furthermore, in both the PD+aCSF (7 days) and PD+Glucagon (7 days) groups, there was a notable decrease in propiomelanocortin (POMC) and agouti-related protein (AgRP). Significant changes were observed in feed consumption and body weight, as well as pancreatic glucagon levels, with a simultaneous decrease in insulin levels in the PD (7 days), Glucagon (7 days), and PD+Glucagon (7 days) groups. These alterations were statistically significant when compared to the control group (p<0.05). CONCLUSIONS: The research outcomes established that pancreas-secreted glucagon functions as a neurohormone within the brain, activating central pathways linked to blood glucose regulation. The presence of glucagon led to a decrease in POMC levels. Surprisingly, this reduction in POMC resulted in the suppression of AgRP. Contrary to expectations, the suppression of AgRP led to an increase in food intake rather than a decrease. As already highlighted in the results section, it was emphasized that POMC may play a more significant role than AgRP in influencing feeding behavior. © 2024 Verduci Editore s.r.l. All rights reserved.en_US
dc.description.sponsorshipInönü Üniversitesi, (TDK 2019/1969); Inönü Üniversitesien_US
dc.identifier.doi10.26355/eurrev_202401_34902
dc.identifier.endpage179en_US
dc.identifier.issn1128-3602
dc.identifier.issue1en_US
dc.identifier.pmid38235868en_US
dc.identifier.scopus2-s2.0-85182954092en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage163en_US
dc.identifier.urihttps://doi.org/10.26355/eurrev_202401_34902
dc.identifier.urihttps://hdl.handle.net/20.500.14619/9045
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Editore s.r.len_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgRPen_US
dc.subjectBrainen_US
dc.subjectGlucagonen_US
dc.subjectGlucose homeostasisen_US
dc.subjectInsulinen_US
dc.subjectPancreasen_US
dc.subjectPOMCen_US
dc.titleEffects of glucagon as a neurohormone on the central nervous system and glucose homeostasisen_US
dc.typeArticleen_US

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