The effects of lycopene on hepatic ischemia/reperfusion injury in rats

Basit Öğe Kaydı
dc.authoridBAYRAMOGLU, AYSEGUL/0000-0001-8567-807X
dc.contributor.authorBayramoglu, Gokhan
dc.contributor.authorBayramoglu, Aysegul
dc.contributor.authorAltuner, Yilmaz
dc.contributor.authorUyanoglu, Mustafa
dc.contributor.authorColak, Suat
dc.date.accessioned2024-09-29T15:51:13Z
dc.date.available2024-09-29T15:51:13Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThere is a very little information about the protective effect of lycopene (LYC) against hepatic ischemia-reperfusion injury. The present study was designed to examine the possible protective effect of the strong antioxidant and anti-inflammatory agent, LYC, on hepatic ischemia/reperfusion injury. For this purpose, rats were subjected to 45 min of hepatic ischemia followed by 60 min of reperfusion period. LYC at the doses of 2.5 and 5 mg/kg body weight (bw) were injected intraperitoneally, 60 min prior to ischemia. Upon sacrification, hepatic tissue samples were used for the measurement of catalase (CAT) activity and malondialdehyde (MDA) levels. Also, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) were assayed in serum samples. As a result of the use of LYC at the doses of 2.5 and 5 mg/kg bw; while improvements of the ALT, AST, LDH and MDA values were partial and dose-dependent, the improvement of CAT activity was total and dose-independent (p < 0.05). Our findings suggest that LYC has a protective effect against ischemia/reperfusion injury on the liver.en_US
dc.identifier.doi10.1007/s10616-014-9706-3
dc.identifier.endpage491en_US
dc.identifier.issn0920-9069
dc.identifier.issn1573-0778
dc.identifier.issue3en_US
dc.identifier.pmid24590927en_US
dc.identifier.scopus2-s2.0-84894563886en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage487en_US
dc.identifier.urihttps://doi.org/10.1007/s10616-014-9706-3
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3936
dc.identifier.volume67en_US
dc.identifier.wosWOS:000351689500010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCytotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia-reperfusionen_US
dc.subjectLiveren_US
dc.subjectLycopeneen_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.titleThe effects of lycopene on hepatic ischemia/reperfusion injury in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu