Education and alcohol use: A study of gene-environment interaction in young adulthood

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dc.authoridKaprio, Jaakko/0000-0002-3716-2455
dc.authoridSalvatore, Jessica/0000-0001-5504-5087
dc.authoridLatvala, Antti/0000-0001-5695-117X
dc.contributor.authorBarr, Peter B.
dc.contributor.authorSalvatore, Jessica E.
dc.contributor.authorMaes, Hermine
dc.contributor.authorAliev, Fazil
dc.contributor.authorLatvala, Antti
dc.contributor.authorViken, Richard
dc.contributor.authorRose, Richard J.
dc.date.accessioned2024-09-29T16:00:43Z
dc.date.available2024-09-29T16:00:43Z
dc.date.issued2016
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe consequences of heavy alcohol use remain a serious public health problem. Consistent evidence has demonstrated that both genetic and social influences contribute to alcohol use. Research on gene environment interaction (GxE) has also demonstrated that these social and genetic influences do not act independently. Instead, certain environmental contexts may limit or exacerbate an underlying genetic predisposition. However, much of the work on GxE and alcohol use has focused on adolescence and less is known about the important environmental contexts in young adulthood. Using data from the young adult wave of the Finnish Twin Study, FinnTwin12 (N = 3402), we used biometric twin modeling to test whether education moderated genetic risk for alcohol use as assessed by drinking frequency and intoxication frequency. Education is important because it offers greater access to personal resources and helps determine one's position in the broader stratification system. Results from the twin models show that education did not moderate genetic variance components and that genetic risk was constant across levels of education. Instead, education moderated environmental variance so that under conditions of low education, environmental influences explained more of the variation in alcohol use outcomes. The implications and limitations of these results are discussed. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipNational Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health [R01AA015416, K02AA018755, F32AA022269]; Academy of Finland [100499, 205585, 118555, 141054, 265240, 263278, 264146]; Scientific and Technological Research Council of Turkey (TUBITAK) [114C117]en_US
dc.description.sponsorshipResearch reported in this publication was supported by the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health under award numbers R01AA015416, K02AA018755, and F32AA022269; the Academy of Finland (grants 100499, 205585, 118555, 141054, 265240, 263278, and 264146); and the Scientific and Technological Research Council of Turkey (TUBITAK) under award number 114C117. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, the Academy of Finland, or the Scientific and Technological Research Council of Turkey.en_US
dc.identifier.doi10.1016/j.socscimed.2016.06.031
dc.identifier.endpage167en_US
dc.identifier.issn0277-9536
dc.identifier.pmid27367897en_US
dc.identifier.scopus2-s2.0-84976351549en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage158en_US
dc.identifier.urihttps://doi.org/10.1016/j.socscimed.2016.06.031
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5321
dc.identifier.volume162en_US
dc.identifier.wosWOS:000381170100018en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofSocial Science & Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectYoung adultsen_US
dc.subjectAlcohol useen_US
dc.subjectEducationen_US
dc.subjectGene-environment interactionen_US
dc.subjectTwin modelsen_US
dc.titleEducation and alcohol use: A study of gene-environment interaction in young adulthooden_US
dc.typeArticleen_US

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