Vitamin E effects on developmental disorders in fetuses and cognitive dysfunction in adults following acrylamide treatment during pregnancy

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dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridTurkoz, Yusuf/0000-0001-5401-0720
dc.authoridYigitcan, Birgul/0000-0002-7910-4595
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorYigitcan, Birgul
dc.contributor.authorAladag, Mehmet Arif
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorCirik, Rumeyza Hilal
dc.date.accessioned2024-09-29T16:02:51Z
dc.date.available2024-09-29T16:02:51Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractWe investigated the effects of acrylamide (AA) and vitamin E treatment during pregnancy on brain tissues of fetuses and on adult rats. Pregnant rats were divided into five groups: control, corn oil, vitamin E, AA, vitamin E +AA. The rats administered AA received10 mg/kg/day and those administered vitamin E received 100 mg/kg/day both by via oral gavage for 20 days. On day 20 of pregnancy, half of the pregnant rats were removed by cesarean section in each group. Morphological development parameters were measured in each fetus and histopathological, biochemical and genetic analyses were conducted on the fetuses. The remaining pregnant rats in each group gave birth to the fetuses vaginally and biochemical, histopathological, genetic and cognitive function tests were conducted when the pups were 8 weeks old. AA administration caused adverse effects on fetus number, fetal weight, crown-rump length, placenta and brain weight. AA negatively affected malondialdehyde, reduced glutathione, total oxidant and antioxidant status, brain derived neurotrophic factor (BDNF) levels, brain tissue morphology, histopathology error score and gene expression (BDNF/beta-actin mRNA ratio) in fetuses. AA administration caused disruption of biochemical, histopathological and cognitive functions in adult rats. Vitamin E provided protection against neurotoxicity in both fetuses and adult rats. We conclude that exposure to AA during pregnancy should be avoided and adequate amounts of antioxidants, such as vitamin E, should be consumed.en_US
dc.description.sponsorshipInonu University Scientific Research Council, Malatya, Turkey [2016/193]en_US
dc.description.sponsorshipThis study was financially sponsored by Inonu University Scientific Research Council, Malatya, Turkey [Project no: 2016/193].en_US
dc.identifier.doi10.1080/10520295.2020.1751880
dc.identifier.endpage19en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue1en_US
dc.identifier.pmid32347129en_US
dc.identifier.scopus2-s2.0-85084304846en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2020.1751880
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5736
dc.identifier.volume96en_US
dc.identifier.wosWOS:000532040100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacrylamideen_US
dc.subjectbrain derived neurotrophic factoren_US
dc.subjectcognitive functionsen_US
dc.subjectneurotoxicityen_US
dc.subjectpostnatal developmenten_US
dc.subjectpregnancyen_US
dc.subjectvitamin Een_US
dc.titleVitamin E effects on developmental disorders in fetuses and cognitive dysfunction in adults following acrylamide treatment during pregnancyen_US
dc.typeArticleen_US

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