Therapeutic Effect of Melatonin on CCl4-Induced Fibrotic Liver Model by Modulating Oxidative Stress, Inflammation, and TGF-?1 Signaling Pathway in Pinealectomized Rats

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridCetinavci, Dilan/0000-0002-4148-7711
dc.contributor.authorCinar, Derya
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorElbe, Hulya
dc.contributor.authorBicer, Yasemin
dc.contributor.authorCetinavci, Dilan
dc.contributor.authorOzturk, Ipek
dc.contributor.authorColak, Tuncay
dc.date.accessioned2024-09-29T15:51:13Z
dc.date.available2024-09-29T15:51:13Z
dc.date.issued2024
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe study aimed to determine the CCl4-induced liver fibrosis model in pinealectomized rats and biochemically, immunohistochemically, and histopathologically investigate the therapeutic effect of melatonin on liver fibrosis. The surgical procedure for pinealectomy was performed at the beginning of the study, and the sham and pinealectomized rats were administered CCl4 dissolved in corn oil (1:1) alone every other day to induce liver fibrosis or together with melatonin (10 mg/kg) therapy for 15 days. Melatonin is an essential therapeutic agent and offers an alternative therapeutic strategy in CCl4-induced liver fibrosis by suppressing inflammation, oxidative stress, and the TGF-beta 1 signaling pathway. Treatment with melatonin ameliorated CCl4-induced liver fibrosis by restoring hepatocellular damage and reducing plasma AST, ALT, and ALP values. Melatonin increases the activity of SOD and CAT, which are important enzymes for antioxidant defence, and raises GSH levels, which further enhances antioxidant function. Also, melatonin reduced hepatic inflammation (IL-6 and IL-1 beta) and oxidative stress indices. Moreover, histopathological changes and immunohistochemical expression of TGF-beta 1 were restored following melatonin supplementation in the CCl4-induced liver fibrosis model in pinealectomized rats. Our study shows that melatonin supplementation has a beneficial effect in protecting the liver fibrosis induced by CCl4 in pinealectomized rats.en_US
dc.description.sponsorshipUniversity of Kocaeli [TDK-21-YL-2695]; Kocaeli University, Department of Scientific Research Projectsen_US
dc.description.sponsorshipThe present study was supported by Kocaeli University, Department of Scientific Research Projects (Project number: TDK-21-YL-2695)en_US
dc.identifier.doi10.1007/s10753-024-02101-7
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.pmid39007940en_US
dc.identifier.scopus2-s2.0-85198647116en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-024-02101-7
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3950
dc.identifier.wosWOS:001267734100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectliver fibrosisen_US
dc.subjectinflammationen_US
dc.subjectoxidative stressen_US
dc.subjectCCl4en_US
dc.subjectpinealectomyen_US
dc.subjectmelatoninen_US
dc.titleTherapeutic Effect of Melatonin on CCl4-Induced Fibrotic Liver Model by Modulating Oxidative Stress, Inflammation, and TGF-?1 Signaling Pathway in Pinealectomized Ratsen_US
dc.typeArticleen_US

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