Fabrication of mechanically advanced polydopamine decorated hydroxyapatite/polyvinyl alcohol bio-composite for biomedical applications: In-vitro physicochemical and biological evaluation

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dc.authoridTURKOZ, MUSTAFA BURAK/0000-0002-4127-7650
dc.contributor.authorErdem, Umit
dc.contributor.authorDogan, Deniz
dc.contributor.authorBozer, Busra M.
dc.contributor.authorTurkoz, Mustafa B.
dc.contributor.authorYildirim, Gurcan
dc.contributor.authorMetin, Aysegul U.
dc.date.accessioned2024-09-29T15:57:42Z
dc.date.available2024-09-29T15:57:42Z
dc.date.issued2022
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn this study, polydopamine (PDA) coated hydroxyapatite (HA) reinforced polyvinyl alcohol (PVA) films were produced to be used in biomedical applications such as bone tissue regeneration. pDA is coated not only to prevent the agglomeration of HA when encountering interstitial fluids but also to strongly bind the PVA for the interaction between materials so that the mechanical performance becomes more stabilized. pDA was coated on the hydroxyapatite surface using a radical polymerization technique, and the reinforced PVA were produced with pDA-coated HA (pDA-HA/PVA) nanoparticles. Fundamental characteristic properties of pDA-HA/PVA nanocomposite films were examined by morphological/chemical (SEM-EDS), microstructural (XRD, Ft-IR, and Raman), thermodynamic (TGA and TM), mechanical performance (Vickers microhardness) and biological activity analysis (MTT, genotoxicity and antimicrobial efficacy investigations). Physicochemical analysis showed that all the samples studied exhibited homogeneous mineral distributions through the main structures. According to TGA, TMA and hardness tests, the new composite structure possessed higher mechanical properties than neat PVA. Further, pDA-HA/PVA nanocomposites exhibited high antibacterial capacities against Acinetobacter Baumannii (A.Baumannii), Staphylococcus aureus (S. aureus), and Streptococcus mutans (S.mutans). Moreover, the new nanocomposites were noted to present good biocompatibility for fibroblast (L929) cells and to support remarkably MCS cells. All in all, this comprehensive work shows that the thermo-mechanically improved pDA-HA/PVA films will increase the application fields of PVA in biomedical fields especially tooth-bone treatments for coating, filling, or occlusion purposes.en_US
dc.description.sponsorshipKirikkale University Research Fund [2022/045, 2020/86]en_US
dc.description.sponsorshipThe authors would like to express their gratitude to Kirikkale University Research Fund for its financial support in spectral analysis. Project Numbers: 2022/045 and 2020/86.en_US
dc.identifier.doi10.1016/j.jmbbm.2022.105517
dc.identifier.issn1751-6161
dc.identifier.issn1878-0180
dc.identifier.pmid36270152en_US
dc.identifier.scopus2-s2.0-85140097598en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jmbbm.2022.105517
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4962
dc.identifier.volume136en_US
dc.identifier.wosWOS:000880893900002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of the Mechanical Behavior of Biomedical Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolyvinyl alcoholen_US
dc.subjectPolydopamineen_US
dc.subjectHydroxyapatiteen_US
dc.subjectNanocompositeen_US
dc.subjectBiocompatibilityen_US
dc.titleFabrication of mechanically advanced polydopamine decorated hydroxyapatite/polyvinyl alcohol bio-composite for biomedical applications: In-vitro physicochemical and biological evaluationen_US
dc.typeArticleen_US

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