Effect of scaffold architecture on cell seeding efficiency: A discrete phase model CFD analysis

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dc.authoridAli, Daver/0000-0002-8500-7820
dc.contributor.authorAli, Davar
dc.date.accessioned2024-09-29T15:55:10Z
dc.date.available2024-09-29T15:55:10Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractWithin perfusion cell culture systems, scaffold architecture is able to control important biological parameters such as permeability and fluid flow-induced shear stress. As well, one of the main factors affecting the final fate of this process as well as optimal cell differentiation and proliferation in these systems is initial adhesion of cells to scaffolds. In this study, the effect of scaffold architecture on the adhesion of the cells was computationally investigated. For this purpose, four scaffold models including double-diamond, gyroid, FR-D, and Schwarz-primitive were designed using triply periodic minimal surface (TPMS) geometry with a constant porosity of 80%. As well, the inlet velocity of zero to simulate static cell culture and three different inlet velocities for modeling the dynamic cell culture conditions were also selected. The results showed that cell culture efficiency of scaffolds could be changed up to seven times from architecture to architecture under the same conditions. The efficiency of cell culture in scaffolds with tortuous architecture was also reported higher than those with relatively straight microchannels. In terms of culture methods, unlike dynamic cell culture model in which almost a homogeneous cell distribution was observed in static cell culture simulation, more cells adhered, but they had agglomerated in the scaffold entrance regions and had failed to reach all regions. The results of this study shed more light on the selection and design of scaffold architecture for optimal cell culture in tissue engineering.en_US
dc.identifier.doi10.1016/j.compbiomed.2019.04.025
dc.identifier.endpage69en_US
dc.identifier.issn0010-4825
dc.identifier.issn1879-0534
dc.identifier.pmid31035072en_US
dc.identifier.scopus2-s2.0-85064624767en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage62en_US
dc.identifier.urihttps://doi.org/10.1016/j.compbiomed.2019.04.025
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4509
dc.identifier.volume109en_US
dc.identifier.wosWOS:000472590500007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofComputers in Biology and Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCell culture efficiencyen_US
dc.subjectTPMS scaffoldsen_US
dc.subjectCFD analysisen_US
dc.subjectDiscrete phase modelingen_US
dc.titleEffect of scaffold architecture on cell seeding efficiency: A discrete phase model CFD analysisen_US
dc.typeArticleen_US

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