Interactive effects of melatonin, exercise and diabetes on liver glycogen levels

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dc.contributor.authorBicer, M.
dc.contributor.authorAkil, M.
dc.contributor.authorAvunduk, M.C.
dc.contributor.authorKilic, M.
dc.contributor.authorMogulkoc, R.
dc.contributor.authorBaltaci, A.K.
dc.date.accessioned2024-09-29T16:22:15Z
dc.date.available2024-09-29T16:22:15Z
dc.date.issued2011
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: This study aimed to examine the effects of melatonin supplementation on liver glycogen levels in rats with streptozotocin-induced diabetes and subjected to acute swimming exercise. Material and methods: Eighty Sprague-Dawley type adult male rats were divided into eight groups: Group 1, general control; Group 2, melatonin-supplemented control; Group 3, melatonin-supplemented diabetes; Group 4, swimming control; Group 5, melatonin-supplemented swimming; Group 6, melatonin-supplemented diabetic swimming; Group 7, diabetic swimming; Group 8, diabetic control. Melatonin was supplemented at a dose of 3 mg/kg/day intraperitoneally for four weeks. Liver tissue samples were collected and evaluated using a Nikon Eclipse E400 light microscope. All images obtained from the light microscope were transferred to PC medium and evaluated using Clemex PE 3.5 image analysis software. Results: The lowest liver glycogen levels in the study were found in group 4. Liver glycogen levels in groups 3, 6, 7 and 8 (the diabetic groups) were higher than group 4, but lower than those in groups 1 and 2. The lowest liver glycogen levels were obtained in groups 1 and 2. Conclusions: The study indicates that melatonin supplementation maintains the liver glycogen levels that decrease in acute swimming exercise, while induced diabetes prevents this maintenance effect in rats.en_US
dc.identifier.endpage255en_US
dc.identifier.issn0423-104X
dc.identifier.issue3en_US
dc.identifier.pmid21717409en_US
dc.identifier.scopus2-s2.0-79960822229en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage252en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14619/9934
dc.identifier.volume62en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEndokrynologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute swimming exerciseen_US
dc.subjectDiabetesen_US
dc.subjectGlycogenen_US
dc.subjectMelatoninen_US
dc.titleInteractive effects of melatonin, exercise and diabetes on liver glycogen levelsen_US
dc.typeArticleen_US

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