The relationship of thiol/disulfide homeostasis in the etiology of patients with obstructive sleep apnea: a case-control study

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dc.authoridHaskul, Ismail/0000-0001-5125-1035
dc.authoridSimsek, Abdullah/0000-0003-0588-3888
dc.authoridEREL, Ozcan/0000-0002-2996-3236
dc.authoridCasim, Hasan/0000-0002-3952-8385
dc.authoridAcat, Murat/0000-0002-7163-4882
dc.authoridneselioglu, salim/0000-0002-0974-5717
dc.contributor.authorDikis, Ozlem Sengoren
dc.contributor.authorAcat, Murat
dc.contributor.authorCasim, Hasan
dc.contributor.authorHaskul, Ismail
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorSimsek, Abdullah
dc.contributor.authorErel, Ozcan
dc.date.accessioned2024-09-29T16:02:52Z
dc.date.available2024-09-29T16:02:52Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractAim: Obstructive sleep apnea syndrome (OSAS) is a chronic and incapacitating disease that often requires lifelong care. This study aimed to evaluate the thiol/disulfide homeostasis in patients with OSAS, to compare the thiol/disulfide levels with the control group and to investigate their relationship with the severity of the disease. Material and methods: Patients who were admitted to the department of chest diseases, and diagnosed with OSAS using polysomnographic analysis (n = 186) and 144 patients who underwent polysomnography due to some reasons but ruled out of having OSAS were included in the study. Serum total thiol (TT), native thiol (SH), and disulfide thiol (SS) levels were measured from the participants; SS/SH, SS/TT, and SH/TT percent ratios were calculated and compared between the patient and control groups. Results: The mean (+/- SD) age of the patients and control participants was 52.0 +/- 11.5 years and 44.9 +/- 13.2 years, respectively. Compared to the control group, patients with OSAS had significantly lower SH (239.3 +/- 56.3 mu mol/L vs. 258.6 +/- 65.3 mu mol/L, t = 2.70, p =.007) and TT levels (273.2 +/- 60.1 mu mol/L vs. 292.9 +/- 67.5 mu mol/L, t = 2.64, p=.010). Age (OR = 1.04), serum albumin (OR = 12.67), ischemia-modified albumin (IMA) (OR = 0.12), SH (OR = 0.81), and TT (OR = 1.17) were independent predictors of OSAS. Conclusions: These results support the idea that decreased ST and TT levels are related to increased oxidative stress. On the other hand, impaired thiol balance may play a significant role in the pathogenesis of OSAS.en_US
dc.identifier.doi10.1080/13685538.2019.1573890
dc.identifier.endpage686en_US
dc.identifier.issn1368-5538
dc.identifier.issn1473-0790
dc.identifier.issue5en_US
dc.identifier.pmid30939975en_US
dc.identifier.scopus2-s2.0-85063745982en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage679en_US
dc.identifier.urihttps://doi.org/10.1080/13685538.2019.1573890
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5765
dc.identifier.volume23en_US
dc.identifier.wosWOS:000464635200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofAging Maleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThiolen_US
dc.subjectdisulfideen_US
dc.subjectoxidative stressen_US
dc.subjectthiolen_US
dc.subjectdisulfide homeostasisen_US
dc.subjectOSASen_US
dc.titleThe relationship of thiol/disulfide homeostasis in the etiology of patients with obstructive sleep apnea: a case-control studyen_US
dc.typeArticleen_US

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