Protective effect of melatonin on lipid peroxidation in various tissues of diabetic rats subjected to an acute swimming exercise

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dc.authoridBaltaci, Abdulkerim Kasim/0000-0003-2461-1212
dc.authoridSivrikaya, Abdullah/0000-0003-2956-5681
dc.authoridMogulkoc, Rasim/0000-0001-6155-6780
dc.authoridBicer, Mursel/0000-0001-8560-5057
dc.contributor.authorBicer, M.
dc.contributor.authorAkil, M.
dc.contributor.authorBaltaci, A. K.
dc.contributor.authorMogulkoc, R.
dc.contributor.authorSivrikaya, A.
dc.contributor.authorGunay, M.
dc.contributor.authorAkkus, H.
dc.date.accessioned2024-09-29T16:08:28Z
dc.date.available2024-09-29T16:08:28Z
dc.date.issued2012
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: The present study aimed to explore the effect of melatonin administration on lipid peroxidation in various tissues of rats with streptozocin induced diabetes and subjected to an acute swimming exercise. Methods: The study used 80 adult male rats, which were equally allocated to 8 groups: Group 1, general control; Group 2, melatonin-administered control; Group 3, melatonin-administered diabetic control; Group 4, swimming control; Group 5, melatonin-administered swimming; Group 6, melatonin-administered diabetic swimming; Group 7, diabetic swimming; Group 8, diabetic control. Diabetic rats were administered 3 mg/kg/day ip melatonin for 4 weeks. At the end of the study, the animals were decapitated to collect samples from liver, lung and spleen tissues, which were then analyzed to determine levels of liver MDA (nmol/gram/protein) and GSH (mg/g/protein). Results: The highest MDA values in liver, lung and spleen tissues were obtained in the Group 7. The values in the Group 8 were lower than those in the Group 7, but higher than in all other groups. The Group 5 and 6 had the highest liver, lung and spleen GSH values. Conclusion: Results obtained from the study indicate that the increase in free radical production and the inhibition of antioxidant activity in diabetes and acute exercise are both prevented by melatonin administration (Tab. 2, Ref. 30). Full Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2012_158
dc.identifier.endpage701en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue12en_US
dc.identifier.pmid23173626en_US
dc.identifier.scopus2-s2.0-84871762947en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage698en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2012_158
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7567
dc.identifier.volume113en_US
dc.identifier.wosWOS:000312349000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdiabetesen_US
dc.subjectexerciseen_US
dc.subjectmelatoninen_US
dc.subjectlipid peroxidationen_US
dc.subjectraten_US
dc.titleProtective effect of melatonin on lipid peroxidation in various tissues of diabetic rats subjected to an acute swimming exerciseen_US
dc.typeArticleen_US

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