Serum eosinophilic cationic protein level and hematological parameters in infants with cow's milk protein allergy

Basit Öğe Kaydı
dc.authoridDOGAN, ERKAN/0000-0003-1620-4123
dc.authoridSEVINC, EYLEM/0000-0003-1778-6559
dc.contributor.authorDogan, Erkan
dc.contributor.authorSevinc, Eylem
dc.date.accessioned2024-09-29T16:06:08Z
dc.date.available2024-09-29T16:06:08Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground Various biomarkers have been investigated in the diagnosis of cow's milk protein allergy (CMPA) in infants. To our knowledge, no prior studies have evaluated serum eosinophil cationic protein (sECP), neutrophil-lymphocyte ratio (NLR), and mean platelet volume (MPV) concurrently in infants with CMPA. Objective To compare sECP levels, MPV, and NLR in infants with and without CMPA, as well as to investigate the suitability of these parameters as biomarkers in the diagnosis of CMPA. Methods Fifty-six children with CMPA were compared to 40 healthy, similar to distribution of age and sex normal infants as controls. The serum ECP levels were detected by a chemiluminescence assay. The MPV values were calculated by devices in hemogram parameters. The NLR values were obtained by dividing the neutrophil count by the lymphocyte count. Results The median sECP level in the CMPA group was significantly higher than in the control group (23.5 and 9.27 ng/ mL, respectively; P=0.001). However, there were no significant differences between groups with regards to median MPV (8.5 and 8.6 fL, respectively; P=0.149) and median NLR (0.35 and 0.37 respectively; P =0.637). Correlation analysis of sECP level with MPV and NLR in the CMPA group revealed no significant relationships (P >0.05 for both). In the Receiver-operating characteristic (ROC) curve analysis, the optimal cut-off levels to identify CMPA for sECP, MPV, and NLR were 18.4 ng/mL (60.7% sensitivity, 97.5% specificity, and AUC: 0.831), 10.05 fL (54% sensitivity, 77.5% specificity, and AUC: 0.413) and 0.97 (14.3% sensitivity, 50% specificity, and AUC: 0.528), respectively. Conclusions The sECP level and blood eosinophil count are significantly higher in infants with CMPA, but MPV and NLR do not differ between infants with and without CMPA. There are also no significant correlations in the CMPA group between sECP and MPV, as well as sECP and NLR. Serum ECP might be useful as a potential biomarker for diagnosing CMPA.en_US
dc.identifier.doi10.14238/pi59.3.2019.119-24
dc.identifier.endpage124en_US
dc.identifier.issn0030-9311
dc.identifier.issn2338-476X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85147678650en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://doi.org/10.14238/pi59.3.2019.119-24
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6640
dc.identifier.volume59en_US
dc.identifier.wosWOS:000473167400002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIndonesian Pediatric Soc Publishing Houseen_US
dc.relation.ispartofPaediatrica Indonesianaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectneutrophil/lymphocyte ratioen_US
dc.subjectmean platelet volumeen_US
dc.subjecteosinophilic cationic proteinen_US
dc.subjectbiomarkeren_US
dc.subjectcow's milk protein allergyen_US
dc.titleSerum eosinophilic cationic protein level and hematological parameters in infants with cow's milk protein allergyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu