Protective effects of crocin on biochemistry and histopathology of experimental periodontitis in rats

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorKocaman, G.
dc.contributor.authorAltinoz, E.
dc.contributor.authorErdemli, M. E.
dc.contributor.authorGul, M.
dc.contributor.authorErdemli, Z.
dc.contributor.authorGul, S.
dc.contributor.authorBag, H. G.
dc.date.accessioned2024-09-29T16:02:51Z
dc.date.available2024-09-29T16:02:51Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractWe investigated the effectiveness of crocin for preventing oxidative damage in experimentally produced periodontitis. We used three groups of 10 female Wistar rats divided into: control (C); experimental periodontitis (EP), experimental periodontitis + crocin (Cr-EP). Malondialdehyde (MDA), glutathione (GSH), total antioxidant status (TAS), total oxidant status (TOS) and superoxide dismutase (SOD) and catalase (CAT) enzyme activities were measured. We examined histopathology and inflammatory cell infiltration in gingiva and periodontal ligament. MDA and TOS levels, and SOD and CAT activities increased significantly in rats with induced periodontitis compared to the control group, while GSH and TAS levels were decreased significantly compared to the control group. Histopathologic examination revealed inflammatory cell infiltration in gingiva epithelium and subepithelial connective tissue in the EP group. Histological damage was reduced significantly after crocin treatment compared to the EP group. Crocin supplementation may help reduce oxidative damage to periodontal tissues.en_US
dc.description.sponsorshipResearch Fund of the Karabuk University [KBU-BAP-17-KP-360]en_US
dc.description.sponsorshipOur work was supported by Research Fund of the Karabuk University [KBU-BAP-17-KP-360].en_US
dc.identifier.doi10.1080/10520295.2019.1571229
dc.identifier.endpage373en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5en_US
dc.identifier.pmid30982354en_US
dc.identifier.scopus2-s2.0-85064495109en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage366en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1571229
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5735
dc.identifier.volume94en_US
dc.identifier.wosWOS:000466679700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrocinen_US
dc.subjectoxidative stressen_US
dc.subjectperiodontal diseaseen_US
dc.subjectperiodontitisen_US
dc.titleProtective effects of crocin on biochemistry and histopathology of experimental periodontitis in ratsen_US
dc.typeArticleen_US

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