Protective effect of indole-3-carbinol on testis of a high fat diet induced obesity

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dc.contributor.authorTufek, Nur Hande
dc.contributor.authorYahyazadeh, Ahmad
dc.contributor.authorAltunkaynak, Berrin Zuhal
dc.date.accessioned2024-09-29T16:02:51Z
dc.date.available2024-09-29T16:02:51Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractWe investigated the effects of obesity caused by a high fat diet (HFD) on rat testes and evaluated the possible protective effects of indole-3-carbinol (IND). We used 24 8-10-week-old 200 g male rats randomly assigned to 4 groups: non-obese control (NC), obese control (OC), non-obese IND group (NI), obese + IND group (OI). Testis samples were examined using stereological, immunohistochemical, biochemical and histological methods. The number of spermatogenic cells, Leydig cells, mean volume of testes and seminiferous tubules was significantly decreased in the OC group compared to the NC group, but these values were increased significantly in the OI group compared to the OC group. We found a significant increase in catalase and myeloperoxidase activities in the OC group compared to the NC group. In the OI group, catalase and myeloperoxidase levels were decreased compared to the OC group. TUNEL-positive cells also were increased in the OC group compared to the NC group (p < 0.05), but these were fewer in the OI group than the OC group. We found marked morphological changes in testicular tissues between the NC and OC groups, as well as between the OI and OC groups. We found that HFD induced obesity was detrimental to rat testes and that administration of IND ameliorated testicular changes caused by obesity.en_US
dc.description.sponsorshipOndokuz Mayis University Project Management Office [TIP.1904.11.023]en_US
dc.description.sponsorshipThis research was supported by the Ondokuz Mayis University Project Management Office [TIP.1904.11.023].en_US
dc.identifier.doi10.1080/10520295.2022.2073612
dc.identifier.endpage12en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue1en_US
dc.identifier.pmid35703014en_US
dc.identifier.scopus2-s2.0-85131911665en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2022.2073612
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5737
dc.identifier.volume98en_US
dc.identifier.wosWOS:000811689100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjecthigh fat dieten_US
dc.subjectimmunohistochemistryen_US
dc.subjectindole-3-carbinolen_US
dc.subjectobesityen_US
dc.subjectraten_US
dc.subjecttestisen_US
dc.titleProtective effect of indole-3-carbinol on testis of a high fat diet induced obesityen_US
dc.typeArticleen_US

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