The effects of lycopene on intestinal injury due to methotrexate in rats

dc.authoridYUCEL, YUSUF CEM/0000-0001-6183-0129
dc.authoridkocarslan, sezen/0000-0002-3512-1588
dc.authoridBuyukaslan, Hasan/0000-0002-4714-7347
dc.contributor.authorYucel, Yusuf
dc.contributor.authorTabur, Suzan
dc.contributor.authorGozeneli, Orhan
dc.contributor.authorKocarslan, Sezen
dc.contributor.authorSeker, Ahmet
dc.contributor.authorBuyukaslan, Hasan
dc.contributor.authorSavik, Emin
dc.date.accessioned2024-09-29T16:05:07Z
dc.date.available2024-09-29T16:05:07Z
dc.date.issued2016
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate the effects of lycopene (Lyc) on methotrexate (Mtx)-induced intestinal damage in rats. Method: Twenty-eight male Sprague Dawley rats were divided into four equal groups: control, Mtx, Lyc, and Mtx-L. Control group: Rats were given only the vehicle. Lyc group: Rats were given Lyc (10 mg/kg) with corn oil by oral gavage for 10 days. Mtx group: Rats were injected intraperitoneally with a single dose of 20 mg/kg of Mtx and given corn oil by oral gavage. Mtx-L group: Rats were treated with Lyc (10 mg/kg) for 10 days after a single dose of Mtx (20 mg/kg). All of the rats were euthanized using terminal anesthesia, and the intestinal tissues were removed for histological examination and for pro-inflammatory cytokine measurement (tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1 beta)), total oxidative status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI). Results: Mtx administration increased histopathological damage and increased TNF-alpha, IL-1 beta, TOS, TAC, and OSI levels in the small intestine tissues. Lyc therapy applied to the Mtx-L group provided significant improvement in all parameters of histopathological damage to the small intestine and significantly reduced the levels of IL-1 beta, TOS, and OSI in the intestinal tissues. Conclusions: The results of this study indicate that Lyc might be useful for protecting intestinal damage induced by Mtx in rats by reducing the increased oxidative stress and pro-inflammatory cytokine (IL-1 beta) levels.en_US
dc.identifier.doi10.1179/1351000215Y.0000000041
dc.identifier.endpage118en_US
dc.identifier.issn1351-0002
dc.identifier.issn1743-2928
dc.identifier.issue3en_US
dc.identifier.pmid26359686en_US
dc.identifier.scopus2-s2.0-84978716166en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.1179/1351000215Y.0000000041
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6521
dc.identifier.volume21en_US
dc.identifier.wosWOS:000376438900003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRedox Reporten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLycopeneen_US
dc.subjectIntestinal injuryen_US
dc.subjectMethotrexateen_US
dc.subjectTNF-alphaen_US
dc.subjectIL-1 betaen_US
dc.subjectOxidative stressen_US
dc.titleThe effects of lycopene on intestinal injury due to methotrexate in ratsen_US
dc.typeArticleen_US

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