The effects of lycopene on intestinal injury due to methotrexate in rats
dc.authorid | YUCEL, YUSUF CEM/0000-0001-6183-0129 | |
dc.authorid | kocarslan, sezen/0000-0002-3512-1588 | |
dc.authorid | Buyukaslan, Hasan/0000-0002-4714-7347 | |
dc.contributor.author | Yucel, Yusuf | |
dc.contributor.author | Tabur, Suzan | |
dc.contributor.author | Gozeneli, Orhan | |
dc.contributor.author | Kocarslan, Sezen | |
dc.contributor.author | Seker, Ahmet | |
dc.contributor.author | Buyukaslan, Hasan | |
dc.contributor.author | Savik, Emin | |
dc.date.accessioned | 2024-09-29T16:05:07Z | |
dc.date.available | 2024-09-29T16:05:07Z | |
dc.date.issued | 2016 | |
dc.department | Karabük Üniversitesi | en_US |
dc.description.abstract | Objective: The aim of this study was to investigate the effects of lycopene (Lyc) on methotrexate (Mtx)-induced intestinal damage in rats. Method: Twenty-eight male Sprague Dawley rats were divided into four equal groups: control, Mtx, Lyc, and Mtx-L. Control group: Rats were given only the vehicle. Lyc group: Rats were given Lyc (10 mg/kg) with corn oil by oral gavage for 10 days. Mtx group: Rats were injected intraperitoneally with a single dose of 20 mg/kg of Mtx and given corn oil by oral gavage. Mtx-L group: Rats were treated with Lyc (10 mg/kg) for 10 days after a single dose of Mtx (20 mg/kg). All of the rats were euthanized using terminal anesthesia, and the intestinal tissues were removed for histological examination and for pro-inflammatory cytokine measurement (tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1 beta)), total oxidative status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI). Results: Mtx administration increased histopathological damage and increased TNF-alpha, IL-1 beta, TOS, TAC, and OSI levels in the small intestine tissues. Lyc therapy applied to the Mtx-L group provided significant improvement in all parameters of histopathological damage to the small intestine and significantly reduced the levels of IL-1 beta, TOS, and OSI in the intestinal tissues. Conclusions: The results of this study indicate that Lyc might be useful for protecting intestinal damage induced by Mtx in rats by reducing the increased oxidative stress and pro-inflammatory cytokine (IL-1 beta) levels. | en_US |
dc.identifier.doi | 10.1179/1351000215Y.0000000041 | |
dc.identifier.endpage | 118 | en_US |
dc.identifier.issn | 1351-0002 | |
dc.identifier.issn | 1743-2928 | |
dc.identifier.issue | 3 | en_US |
dc.identifier.pmid | 26359686 | en_US |
dc.identifier.scopus | 2-s2.0-84978716166 | en_US |
dc.identifier.scopusquality | Q2 | en_US |
dc.identifier.startpage | 113 | en_US |
dc.identifier.uri | https://doi.org/10.1179/1351000215Y.0000000041 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14619/6521 | |
dc.identifier.volume | 21 | en_US |
dc.identifier.wos | WOS:000376438900003 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor & Francis Ltd | en_US |
dc.relation.ispartof | Redox Report | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Lycopene | en_US |
dc.subject | Intestinal injury | en_US |
dc.subject | Methotrexate | en_US |
dc.subject | TNF-alpha | en_US |
dc.subject | IL-1 beta | en_US |
dc.subject | Oxidative stress | en_US |
dc.title | The effects of lycopene on intestinal injury due to methotrexate in rats | en_US |
dc.type | Article | en_US |