Protective effect of Smilax excelsa L. pretreatment via antioxidant, anti-inflammatory effects, and activation of Nrf-2/HO-1 pathway in testicular torsion model

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dc.authoridAYDIN, TUBA/0000-0002-7653-6480
dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.contributor.authorCellat, Mustafa
dc.contributor.authorIsler, Cafer Tayer
dc.contributor.authorUyar, Ahmet
dc.contributor.authorKuzu, Muslum
dc.contributor.authorAydin, Tuba
dc.contributor.authorEtyemez, Muhammed
dc.contributor.authorTurk, Erdinc
dc.date.accessioned2024-09-29T16:04:41Z
dc.date.available2024-09-29T16:04:41Z
dc.date.issued2022
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe protective effects of the ethanol extract of Smilax excelsa L. (SE) leaves were investigated on testicular tissue of rats with a torsion model in this study. The chemical composition of the extract was detected by means of liquid chromatography with tandem mass spectrometry (LC-MS/MS). SE extract was given for 21 days before torsion was created in the treatment group. The sperm parameters of the torsion group were impaired, and there was an increase in MDA level as well as a decrease in GSH level and GPx activity compared to the control group. TNF-alpha and NF-kappa B levels in the torsion group increased as compared to those in the control group. The expression levels of Nrf-2 and HO-1 were lower in the torsion group than those in the control group. The SE pretreatment group has improved sperm, oxidative stress, and inflammatory markers when compared to the torsion group, and the Nrf-2/HO-1 pathway was activated. Practical applications Smilax excelsa L. is a plant with economic value used in traditional medicine in the treatment of stomachache, bloating, and breast cancer in Northwest Anatolia. It has an antioxidant effect due to the flavonoids and anthocyanins it contains. The protective effect against ischemia-reperfusion-induced tissue and reproductive damage in testicular tissue were demonstrated with the study. When the histological examinations of the tissues were evaluated, it was found that morphological structure of the tissues was retained in the treatment group. The findings indicate that SE prevents tissue damage in the torsion model by antioxidant and anti-inflammatory effects and activating Nrf-2/HO-1 pathway.en_US
dc.description.sponsorshipScientific Research Project Coordination of the Hatay Mustafa Kemal University, Turkey [20, 004]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Project Coordination of the Hatay Mustafa Kemal University, Turkey [grant numbers 20.M. 004]en_US
dc.identifier.doi10.1111/jfbc.14161
dc.identifier.issn0145-8884
dc.identifier.issn1745-4514
dc.identifier.issue8en_US
dc.identifier.pmid35347733en_US
dc.identifier.scopus2-s2.0-85127244179en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/jfbc.14161
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6258
dc.identifier.volume46en_US
dc.identifier.wosWOS:000773801600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Food Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectinflammationen_US
dc.subjectoxidative stressen_US
dc.subjectSmilax excelsa Len_US
dc.subjecttestis torsionen_US
dc.titleProtective effect of Smilax excelsa L. pretreatment via antioxidant, anti-inflammatory effects, and activation of Nrf-2/HO-1 pathway in testicular torsion modelen_US
dc.typeArticleen_US

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