Mean platelet volume and platelet distribution width correlates with prognosis of early colon cancer

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dc.contributor.authorSakin, A.
dc.contributor.authorSahin, S.
dc.contributor.authorSakin, A.
dc.contributor.authorKaratas, F.
dc.contributor.authorSamanci, N.S.
dc.contributor.authorYasar, N.
dc.contributor.authorArici, S.
dc.date.accessioned2024-09-29T16:22:32Z
dc.date.available2024-09-29T16:22:32Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPurpose: Several platelet indices have been linked to prognosis of various cancers, including metastatic colorectal cancer. The aim of this study was to investigate the prognostic effect of mean platelet volume (MPV) and platelet distribution width (PDW) in early colon cancer (CC) patients. Methods: This retrospective study included early CC patients who were followed up and treated between 2005 and 2017. Relapse free survival (RFS) and overall survival (OS) were determined with respect to several demographic and clinical characteristics of patients, including MPV and PDW. The cut-off value was determined as >8.5 fL for MPV (sensitivity: 67.1%, specificity 54.5%) and ?16% for PDW (sensitivity: 66.7%, specificity: 60.0%). Results: The study included 394 patients, 53.3% of which were male. Stage I, II, and III patients constituted 8.9%, 46.4%, and 44.7% of the study population, respectively. Among all patients, RFS and OS were significantly longer in patients with MPV?8.5 fL and PDW>16 fL (p<0.001 and p=0.011 for MPV, respectively; and p<0.001 and p=0.026 for PDW, respectively). In patients with stage III disease, those with MPV?8.5 fL had significantly longer RFS and OS compared to those with MPV >8.5 fL (p<0.001 and p=0.001, respectively). On the other hand, those with PDW>16% had significantly longer RFS than that in those with PDW ?16 fL among stage III patients (p<0.001). In multivariate analysis, stage, perineural invasion, lymphovascular invasion, adjuvant treatment, CEA, CA19-9, PDW, and MPV were found the most significant factors affecting RFS. Conclusion: Our study suggests that elevated MPV and decreased PDW appear to be unfavorable prognostic factors in early CC, especially in patients with stage III disease. Considering the wide availability and accessibility of these indices, it is reasonable to designate further larger prospective studies to clarify and verify their potential roles in early CC. © This work by JBUON is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.identifier.endpage239en_US
dc.identifier.issn1107-0625
dc.identifier.issue1en_US
dc.identifier.pmid32277636en_US
dc.identifier.scopus2-s2.0-85081638399en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage227en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14619/10124
dc.identifier.volume25en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherZerbinis Publicationsen_US
dc.relation.ispartofJournal of B.U.ON.en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColon canceren_US
dc.subjectMean platelet volumeen_US
dc.subjectOveral survivalen_US
dc.subjectPlatelet distribution widthen_US
dc.subjectRelapse free survivalen_US
dc.titleMean platelet volume and platelet distribution width correlates with prognosis of early colon canceren_US
dc.typeArticleen_US

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