Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis

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dc.authoridOzgul Onal, Melike/0000-0001-6710-5729
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridDEMIR, MEHMET/0000-0001-6990-3337
dc.contributor.authorBallur, Arwa Fadil Haqi
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorOnal, Melike Ozgul
dc.contributor.authorElbe, Hulya
dc.contributor.authorBicer, Yasemin
dc.contributor.authorKarayakali, Melike
dc.date.accessioned2024-09-29T15:51:13Z
dc.date.available2024-09-29T15:51:13Z
dc.date.issued2022
dc.departmentKarabük Üniversitesien_US
dc.description.abstractGout is an inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints or soft tissue. MSU crystals are potent inflammation inducers. Melatonin (MLT) is a powerful endogenous anti-inflammatory agent and effective in reducing cellular damage. In the present study, possible underlying mechanisms associated with anti-inflammatory and antioxidative effects were investigated in rats with gouty arthritis and melatonin deprivation treated with MLT. Fifty-six rats were divided into seven groups: control, sham control, pinealectomy (PNX), MSU (on the 30th day, single-dose 20 mg/ml, intraperitoneal), MSU + MLT (10 mg/kg/day for 30 days, intraperitoneal), MSU + PINX and MSU + PINX + MLT. PNX procedure was performed on the first day of the study. As compared to the controls, the results showed that MSU administration caused significant increases in oxidative stress parameters (malondialdehyde and total oxidant status). Besides, significant decreases in antioxidant defense systems (glutathione, superoxide dismutase and total antioxidant status) were observed. A statistically significant increase was found in the mean histopathological damage score in the groups that received MSU injection. It was found that histopathological changes were significantly reduced in the MSU + MLT group given MLT. In our study, it was determined that many histopathological changes, as well as swelling and temperature increase in the joint, which are markers of inflammation, were significantly reduced with MLT supplementation. These results suggest that melatonin ameliorates MSU-induced gout in the rat through inhibition of oxidative stress and proinflammatory cytokine production.en_US
dc.description.sponsorshipKarabuk University Scientific Research Fund [TSA-2020-2346]en_US
dc.description.sponsorshipThe research was supported by Karabuk University Scientific Research Fund (TSA-2020-2346).en_US
dc.identifier.doi10.1007/s10753-022-01623-2
dc.identifier.endpage1347en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue3en_US
dc.identifier.pmid35039996en_US
dc.identifier.scopus2-s2.0-85123122083en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1332en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-022-01623-2
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3949
dc.identifier.volume45en_US
dc.identifier.wosWOS:000743400200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGouten_US
dc.subjectMonosodium urate crystalsen_US
dc.subjectMelatoninen_US
dc.subjectOxidative stressen_US
dc.subjectPinealectomyen_US
dc.subjectRaten_US
dc.titleInfluence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritisen_US
dc.typeArticleen_US

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