Exploring Regional Disparities in Heart Failure Epidemiology and Outcomes: A Comprehensive Study Across Geographical Regions in Türkiye

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dc.authoridColluoglu, Tugce/0000-0002-2227-6177
dc.authoridYILMAZ, MEHMET BIRHAN/0000-0002-8169-8628
dc.authoridSahin, Anil/0000-0003-3416-5965
dc.contributor.authorSahin, Anil
dc.contributor.authorCoellueoglu, Tugce
dc.contributor.authorCelik, Ahmet
dc.contributor.authorAta, Naim
dc.contributor.authorYilmaz, Mehmet Birhan
dc.contributor.authorUral, Dilek
dc.contributor.authorKanik, Arzu
dc.date.accessioned2024-09-29T16:08:30Z
dc.date.available2024-09-29T16:08:30Z
dc.date.issued2024
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: Heart failure (HF) is a common condition that affects 1-3% of the general population. Its prevalence exhibits notable international and intranational disparities, partly explained by socioeconomic status, religion, ethnic diversity, and geographic factors. A comprehensive understanding of the epidemiological symptoms of HF in different regions of Turkiye has yet to be revealed. Aims: To examine epidemiological data from 2016 to 2022, focusing on crucial patient characteristics and geographical regions, to determine the incidence and prevalence of HF in Turkiye across seven diverse geographical regions.Study Design: A nationwide population-based retrospective cohort study.Methods: The comprehensive National Electronic Database of the Turkish Ministry of Health was used in this study to obtain data that covers the whole Turkish population from January 1, 2016, to December 31, 2022. The International Classification of Diseases-10 (ICD-10) codes were used to identify adults with HF (n = 2,701,099) and associated comorbidities. Turkiye is divided into seven geographically distinct regions. Epidemiological characteristics and survival data of these regions were analyzed separately. All-cause mortality was set as the primary outcome. Results: In , the total estimated prevalence of adult patients with HF is 2.939%, ranging from 2.442% in Southeastern Anatolia to 4.382% in the Black Sea Region. Except for the Eastern Anatolia Region, the three most often reported comorbidities were hypertension, dyslipidemia, and anxiety disorders. The rates of prescribing guideline-directed medical therapy (GDMT) for HF and other medications varied significantly. GDMT prescription rates were lowest in the Eastern Anatolia Region (82.6% for beta-blockers, 48.7% for RASi, 31.8% for mineralocorticoid receptor antagonists, and 9.4% for SGLT2i). The Mediterranean and Aegean regions had the highest median N-terminal brain natriuretic peptide (NT-proBNP) levels of 1,990,0 pg/ml (518.0-6,636,0) and 1,441,0 pg/ml (363.0-5,000,0), respectively. From 2016 to 2022, 915,897 (33.9%) of 2,701,099 patients died. The Eastern Anatolia Region had the lowest all-cause mortality rate of 26.5%, whereas the Black Sea Region had the highest all-cause mortality rate of 35.3%.Conclusion: Our real-world analysis revealed geographic disparities in HF characteristics, such as decreased mortality in socioeconomically challenged regions. Higher stress susceptibility in developed regions may increase the likelihood of adverse outcomes.en_US
dc.identifier.doi10.4274/balkanmedj.galenos.2023.2023-10-5
dc.identifier.endpage53en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue1en_US
dc.identifier.pmid38173192en_US
dc.identifier.scopus2-s2.0-85181626956en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage47en_US
dc.identifier.trdizinid1263689en_US
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.galenos.2023.2023-10-5
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1263689
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7590
dc.identifier.volume41en_US
dc.identifier.wosWOS:001146244200007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRisk-Factoren_US
dc.subjectMortalityen_US
dc.subjectDiseaseen_US
dc.subjectAnxietyen_US
dc.titleExploring Regional Disparities in Heart Failure Epidemiology and Outcomes: A Comprehensive Study Across Geographical Regions in Türkiyeen_US
dc.typeArticleen_US

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