Effect of 0.12% Chlorhexidine Use for Oral Care on Ventilator-Associated Respiratory Infections: A Randomized Controlled Trial

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dc.contributor.authorKes, Duygu
dc.contributor.authorAydin Yildirim, Tugba
dc.contributor.authorKuru, Cuneyt
dc.contributor.authorPazarlioglu, Fatma
dc.contributor.authorCiftci, Taner
dc.contributor.authorOzdemir, Mehmet
dc.date.accessioned2024-09-29T16:03:11Z
dc.date.available2024-09-29T16:03:11Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: Evidence suggests that the effect of 0.12% chlorhexidine (CHX) use for oral care on the development of ventilator-associated pneumonia (VAP) and ventilator-associated tracheobronchitis (VAT) is lacking. Evidence-based approaches to the prevention of VAP and VAT are of paramount importance for improving patients' outcomes. Objectives: This study aimed to (1) compare the effect of 0.12% CHX use for oral care on preventing VAP and VAT with the placebo group, as well as (2) compare its effect on oral health and prevention of oral microbial colonization with the placebo group. Methods: Prospective, single-blinded, randomized controlled trial performed in 2 intensive care units at a hospital. The sample comprised 57 mechanically ventilated adults randomly allocated to the 0.12% CHX group and the placebo group. Barnason's oral assessment guide was used to evaluate the oral health of both groups before oral care during the first 24 hr of tracheal intubation (Day 0) and at Day 2 and Day 3. Oropharyngeal secretion, endotracheal tube aspirate, and nonbronchoscopic bronchoalveolar lavage samples were collected on Day 0 and Day 3. Results: The rate of VAT development was not statistically different between the groups (p = .318). However, a significant difference existed in the rate of VAP development (p = .043). The frequency of oropharyngeal colonization significantly decreased in the 0.12% CHX group compared with the placebo group at Day 3 (p = .001). Conclusion: The use of 0.12% CHX for oral care could be effective for VAP prevention and reducing microbial colonization in mechanically ventilated patients.en_US
dc.description.sponsorshipKarabuk University Scientific Research Projects Coordination Unit [TDT-2019-2091]en_US
dc.description.sponsorshipThis work was supported by Karabuk University Scientific Research Projects Coordination Unit (Grant No. TDT-2019-2091).en_US
dc.identifier.doi10.1097/JTN.0000000000000590
dc.identifier.endpage234en_US
dc.identifier.issn1078-7496
dc.identifier.issn1932-3883
dc.identifier.issue4en_US
dc.identifier.pmid34210941en_US
dc.identifier.scopus2-s2.0-85110277594en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage228en_US
dc.identifier.urihttps://doi.org/10.1097/JTN.0000000000000590
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5931
dc.identifier.volume28en_US
dc.identifier.wosWOS:000673611300006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Trauma Nursingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChlorhexidineen_US
dc.subjectOral careen_US
dc.subjectOral hygieneen_US
dc.subjectVentilator-associated pneumoniaen_US
dc.subjectVentilator-associated tracheobronchitisen_US
dc.titleEffect of 0.12% Chlorhexidine Use for Oral Care on Ventilator-Associated Respiratory Infections: A Randomized Controlled Trialen_US
dc.typeArticleen_US

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