The interaction between a zinc(II) phthalocyanine compound bearing octakis phenoxyacetamide substituents and calf thymus DNA

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dc.authoridAGIRTAS, MEHMET SALIH/0000-0003-1296-2066
dc.contributor.authorArslantas, Ali
dc.contributor.authorAgirtas, Mehmet Salih
dc.date.accessioned2024-09-29T16:08:20Z
dc.date.available2024-09-29T16:08:20Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn this study, a zinc(II) phthalocyanine compound (PcZn) substituted with octakis phenoxyacetamide was synthesized and characterized. Calf thymus DNA (CT-DNA) was used to determine the DNA binding properties of the zinc(II) phthalocyanine compound. This interaction of CT-DNA with PcZn was investigated using electronic absorption spectra, emission spectroscopy, a thermal melting temperature study, cyclic voltammetry, and viscosity measurements in a Tris-HCl buffer solution at a pH of 7.2. The findings showed that zinc(II) phthalocyanine interacts with calf thymus DNA via partial intercalative binding mechanisms. In addition to the techniques above, a gel electrophoresis study was also carried out to verify the interaction of CT-DNA with the PcZn complex. The results demonstrated that the octakis phenoxyacetamide-substituted zinc(II) phthalocyanine complex binds to CT-DNA via a partial intercalative binding mode.en_US
dc.description.sponsorshipCommission of Scientific Research Projects of Karabuk Universityen_US
dc.description.sponsorshipThis work was supported by the Commission of Scientific Research Projects of Karabuk University.en_US
dc.identifier.doi10.3906/kim-1805-18
dc.identifier.endpage1320en_US
dc.identifier.issn1300-0527
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85054904942en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1310en_US
dc.identifier.trdizinid381733en_US
dc.identifier.urihttps://doi.org/10.3906/kim-1805-18
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/381733
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7501
dc.identifier.volume42en_US
dc.identifier.wosWOS:000451313100010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDNA bindingen_US
dc.subjectabsorption spectroscopyen_US
dc.subjectgel electrophoresisen_US
dc.subjectthermal meltingen_US
dc.subjectphthalocyanine compounden_US
dc.titleThe interaction between a zinc(II) phthalocyanine compound bearing octakis phenoxyacetamide substituents and calf thymus DNAen_US
dc.typeArticleen_US

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