Synthesis, Characterization, Antimicrobial Activity and in Silico Studies of Some Phenyl, Furyl and 1H-1,2,4-Triazole Substituted Benzyl and Alkyl Ethers

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dc.contributor.authorGüven, Ö.Ö.
dc.contributor.authorTahtaci, H.
dc.contributor.authorAltanlar, N.
dc.contributor.authorAlici, H.
dc.date.accessioned2024-09-29T16:21:20Z
dc.date.available2024-09-29T16:21:20Z
dc.date.issued2022
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn this study, a series of phenyl, furyl and 1H-1,2,4-triazole substituted benzyl and alkyl ethers were synthesized, characterized by all spectral analysis, and evaluated for their antibacterial and antifungal activities against Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Candida albicans and Candida krusei. From phenyl substituted series, compound 1-(2-(3,4-dichlorobenzyloxy)-2-phenylethyl)-1H-1,2,4-triazole (7 i) exhibited the most potent antibacterial activity with lowest MIC value of 6.25 ?g/mL against MRSA and from furyl substituted series, most of the compounds exhibited the most potent antifungal activity with lowest MIC value of 6.25 ?g/mL against Candida Krusei. Furthermore, the absorption, distribution, metabolism, and excretion (ADME) and drug-likeness characteristic of the compounds were calculated, and it was observed that all compounds met majority the criteria of five different drug filters. Finally, docking simulations revealed that some compounds showed high affinity to an CYP51 antifungal target structure (PDB: 3L4D). © 2022 Wiley-VCH GmbH.en_US
dc.description.sponsorshipZonguldak Karaelmas University, (2008?13?02?06)en_US
dc.identifier.doi10.1002/slct.202202046
dc.identifier.issn2365-6549
dc.identifier.issue35en_US
dc.identifier.scopus2-s2.0-85139119192en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/slct.202202046
dc.identifier.urihttps://hdl.handle.net/20.500.14619/9688
dc.identifier.volume7en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofChemistrySelecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1,2,4-triazoleen_US
dc.subjectADMEen_US
dc.subjectalkyl and benzyl etheren_US
dc.subjectantimicrobialen_US
dc.subjectmolecular dockingen_US
dc.titleSynthesis, Characterization, Antimicrobial Activity and in Silico Studies of Some Phenyl, Furyl and 1H-1,2,4-Triazole Substituted Benzyl and Alkyl Ethersen_US
dc.typeArticleen_US

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