Ameliorative effects of crocin on the inflammation and oxidative stress-induced kidney damages by experimental periodontitis in rat

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorGul, Mehmet
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorGul, Semir
dc.contributor.authorKocaman, Gulhan
dc.contributor.authorKustepe, Elif Kayhan
dc.date.accessioned2024-09-29T16:06:42Z
dc.date.available2024-09-29T16:06:42Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective(s): The present study aimed to investigate the effects of periodontitis on kidneys and the protective role of crocin in periodontitis-induced kidney damage. Materials and Methods: Ethics committee approval was obtained and 30 Wistar rats were randomly divided into 3 groups of 10 rats: Control (C), Periodontitis (P), and Periodontitis + Crocin (P + Cr). After the treatments, rat kidney tissues were incised under anesthesia and blood samples were collected. Biochemical and histopathological analyses were conducted on the samples. Results: Malondialdehyde (MDA), total oxidant status (TOS), and oxidative stress index (OSI) increased in P group rat kidney tissues; urea, creatinine, Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin 1 beta (IL-1 beta) levels increased in the serum; glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels were reduced in rat kidney tissues, and renal histopathology deteriorated. In the P + Cr group, we observed improvements in biochemical and histopathological parameters when compared with the P group. Conclusion: Periodontitis (P) led to deterioration in oxidative stress parameters and histopathology by increasing the oxidants in kidney tissue. P also led to inflammation in the blood of the rats. Periodontitis + Crocin (P + Cr) administration alleviated the effects of P due to powerful antioxidant anti-inflammatory properties. Cr could be employed as a protective agent in P-induced inflammation and oxidative damage.en_US
dc.identifier.doi10.22038/ijbms.2021.55875.12499
dc.identifier.endpage832en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue6en_US
dc.identifier.pmid34630960en_US
dc.identifier.scopus2-s2.0-85108515758en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage825en_US
dc.identifier.urihttps://doi.org/10.22038/ijbms.2021.55875.12499
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7003
dc.identifier.volume24en_US
dc.identifier.wosWOS:000657429800014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.relation.ispartofIranian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrocinen_US
dc.subjectInflammationen_US
dc.subjectKidney damageen_US
dc.subjectOxidative stressen_US
dc.subjectPeriodontitisen_US
dc.subjectRaten_US
dc.titleAmeliorative effects of crocin on the inflammation and oxidative stress-induced kidney damages by experimental periodontitis in raten_US
dc.typeArticleen_US

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