The effects of crocin (active contstituent of saffron) treatment on brain antioxidant enzyme mRNA levels in diabetic rats

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorEkici, Cemal
dc.contributor.authorOzyazgan, Berna
dc.contributor.authorCigremis, Yilmaz
dc.date.accessioned2024-09-29T16:06:17Z
dc.date.available2024-09-29T16:06:17Z
dc.date.issued2016
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: The aim of the present study is to evaluate the effect of crocin on mRNA expression of antioxidant enzymes, SOD, CAT and GPX in the brain of the STZ induced diabetic rats. Methods: Thirty animals randomized in three groups containing ten animals in each group as follows; control (non-diabetic rats), DM (STZ-induced untreated diabetic rats), DM+crocin (STZ-induced diabetic rats treated with crocin,). Crocin was given at a dose of 20 mg/kg bw/day by gavage for 21 days. Results: STZ injection caused a significant increase in mRNA expression of antioxidant enzymes, SOD, CAT and GPX when compared to control group. Crocin given to diabetic rats significantly decreased mRNA expression of antioxidant enzymes, SOD, CAT and GPX when compared to DM group. Conclusion: The present study demonstrates that crocin can modulate mRNA expression of antioxidant enzymes, SOD, CAT and GPX and oxidative stress in the brain of the STZ induced diabetic rats.en_US
dc.description.sponsorshipScientific Research Fund of Karabuk University [KBU-BAP-14/1-KA-042]en_US
dc.description.sponsorshipThis study was sponsored by a grant from Scientific Research Fund of Karabuk University (Grant number: KBU-BAP-14/1-KA-042).en_US
dc.identifier.doi10.1515/tjb-2016-0018
dc.identifier.endpage117en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84962384824en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage112en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2016-0018
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6733
dc.identifier.volume41en_US
dc.identifier.wosWOS:000376239300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCrocinen_US
dc.subjectantioxidant enzyme genesen_US
dc.subjectbrainen_US
dc.subjectdiabetes mellitusen_US
dc.subjectmRNAen_US
dc.titleThe effects of crocin (active contstituent of saffron) treatment on brain antioxidant enzyme mRNA levels in diabetic ratsen_US
dc.typeArticleen_US

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