Alcohol Metabolizing Polygenic Risk for Alcohol Consumption in European American College Students

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dc.authoridEdwards, Alexis/0000-0002-4006-9710
dc.authoridThomas, Nathaniel/0000-0001-6291-0518
dc.authoridChartier, Karen/0000-0002-2410-2584
dc.authoridWebb, Bradley/0000-0002-0576-5366
dc.contributor.authorThomas, Nathaniel S.
dc.contributor.authorAdkins, Amy
dc.contributor.authorAliev, Fazil
dc.contributor.authorEdwards, Alexis C.
dc.contributor.authorWebb, Bradley T.
dc.contributor.authorTiarsmith, E. Clare
dc.contributor.authorKendler, Kenneth S.
dc.date.accessioned2024-09-29T16:06:18Z
dc.date.available2024-09-29T16:06:18Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: Evidence suggests that the nature and magnitude of some genetic effects on alcohol use vary by age. We tested for moderation in the effect of an alcohol metabolizing polygenic score by time across the college years. Method: Participants (total n = 2,214) were drawn from three cohorts of undergraduate college students, who were assessed annually for up to 4 years starting in their freshman year. Polygenic risk scores (PRSs) were calculated from genes involved in the metabolism of alcohol, as many of these markers are among the best replicated in association studies examining alcohol use phenotypes. Linear mixed effects models were fit by maximum likelihood to test the main effects of time and the PRS on alcohol consumption, as well as moderation of the PRS effect on alcohol consumption by time. Results: In the main effects model, the fixed effects for time and the PRS were positively associated with alcohol consumption. The interaction term testing moderation of the PRS effect by time reached statistical significance and remained statistically significant after other relevant interaction effects were controlled for. The main effect of the PRS accounted for 0.2% of the variance in alcohol consumption, whereas the interaction of PRS effect and time accounted for 0.05%. Conclusions: Alcohol metabolizing genetic effects on alcohol use appear to be more influential in later years of college than in earlier years. Shifting environmental contexts, such as increased access to alcohol as individuals approach the legal age to purchase alcohol, may account for this association.en_US
dc.description.sponsorshipNational Institute on Alcohol Abuse and Alcoholism (NIAAA) [K01AA021145]; Virginia Commonwealth University; NIAAA [P20AA107828, R37AA011408, K02AA018755, K01AA021399, P50AA022537]; National Center for Research Resources and National Institutes of Health Roadmap for Medical Research [UL1RR031990]en_US
dc.description.sponsorshipThis work is supported by National Institute on Alcohol Abuse and Alcoholism (NIAAA) Grant K01AA021145. Spit for Science: The Virginia Commonwealth University Student Survey has been supported by Virginia Commonwealth University; NIAAA Grants P20AA107828, R37AA011408, K02AA018755, K01AA021399, and P50AA022537; and National Center for Research Resources and National Institutes of Health Roadmap for Medical Research Grant UL1RR031990.en_US
dc.identifier.doi10.15288/jsad.2018.79.627
dc.identifier.endpage634en_US
dc.identifier.issn1937-1888
dc.identifier.issn1938-4114
dc.identifier.issue4en_US
dc.identifier.pmid30079879en_US
dc.identifier.scopus2-s2.0-85055696098en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage627en_US
dc.identifier.urihttps://doi.org/10.15288/jsad.2018.79.627
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6739
dc.identifier.volume79en_US
dc.identifier.wosWOS:000441178300016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAlcohol Res Documentation Inc Cent Alcohol Stud Rutgers Univen_US
dc.relation.ispartofJournal of Studies On Alcohol and Drugsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSubstance Useen_US
dc.subjectEnvironment Interactionen_US
dc.subjectHeavy Drinkingen_US
dc.subjectUse Disordersen_US
dc.subjectDependenceen_US
dc.subjectAssociationen_US
dc.subjectGenesen_US
dc.subjectTransitionen_US
dc.subjectBiologyen_US
dc.subjectSampleen_US
dc.titleAlcohol Metabolizing Polygenic Risk for Alcohol Consumption in European American College Studentsen_US
dc.typeArticleen_US

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