Crocin protects intestine tissue against carbon tetrachloride-mediated oxidative stress in rats

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorCosgun, Binnaz E.
dc.contributor.authorErdemli, Mehmet E.
dc.contributor.authorGul, Mehmet
dc.contributor.authorGul, Semir
dc.contributor.authorBag, Harika G.
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorAltinoz, Eyup
dc.date.accessioned2024-09-29T16:08:29Z
dc.date.available2024-09-29T16:08:29Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractSaffron is used in traditional medicine for its hypolipidemic, anti-inflammatory and anti carcinogenic properties as a natural remedy in treatment of diseases. The objective of the present study was to demonstrate the protective effect of crocin (one of the main ingredients of saffron) on carbon tetrachloride (CCl4) damage in intestinal mucosa. MDA, GSH, SOD, CAT, TAS and TOS levels were measured in experimental animal tissue samples and these were compared with histologic lesions induced by CCl4.CCl4 caused an increase in MDA, SOD, CAT and TOS levels and a significant decrease in GSH and TAS levels in rat intestinal tracts. After crocin treatment, serious improvements were observed in histological lesions and biochemical results in the intestinal tract. In conclusion, crocin inhibited the toxic effects induced by CCl4 in the intestine by its strong antioxidant properties.en_US
dc.description.sponsorshipKarabuk University scientific research fund [KBU-BAP-15/2-YL-009]en_US
dc.description.sponsorshipThe present study was sponsored by Karabuk University scientific research fund. (KBU-BAP-15/2-YL-009).en_US
dc.identifier.doi10.4149/gpb_2017057
dc.identifier.endpage409en_US
dc.identifier.issn0231-5882
dc.identifier.issn1338-4325
dc.identifier.issue4en_US
dc.identifier.pmid30220678en_US
dc.identifier.scopus2-s2.0-85052058122en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage399en_US
dc.identifier.urihttps://doi.org/10.4149/gpb_2017057
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7578
dc.identifier.volume37en_US
dc.identifier.wosWOS:000442487900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAepress Sroen_US
dc.relation.ispartofGeneral Physiology and Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCCl4en_US
dc.subjectCrocinen_US
dc.subjectOxidative stressen_US
dc.subjectMDAen_US
dc.subjectIntestineen_US
dc.titleCrocin protects intestine tissue against carbon tetrachloride-mediated oxidative stress in ratsen_US
dc.typeArticleen_US

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