Microvawe assisted synthesis of N-(methyl and methoxy) benzylidene-4-fluoroaniline derivatives and their carbonic anhydrase I and II inhibition properties

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dc.contributor.authorCelik, Hulya
dc.contributor.authorKuzu, Muslum
dc.date.accessioned2024-09-29T16:07:45Z
dc.date.available2024-09-29T16:07:45Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn this study, some Schiff base derivatives (6a-f) were synthesized using a microwave method. The synthesized compounds were characterized by 1D, 2D NMR and mass spectral data. Their inhibitory effects were studied on carbonic anhydrase isozymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-L-tyrosine-sulfanilamide affinity chromatography and the compounds N-3-Methylbenzylidene-4-fluoroaniline (6b), N-4-Methylbenzylidene-4-fluoroaniline (6c), N-2-Methoxybenzylidene-4-fluoroaniline (6d) showed moderate activity on hCAII in the range of IC50 values.en_US
dc.identifier.doi10.25135/acg.oc.66.19.07.1327
dc.identifier.endpage216en_US
dc.identifier.issn1307-6175
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85078847444en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage210en_US
dc.identifier.urihttps://doi.org/10.25135/acg.oc.66.19.07.1327
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7148
dc.identifier.volume12en_US
dc.identifier.wosWOS:000504859200004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcg Publicationsen_US
dc.relation.ispartofOrganic Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSchiff baseen_US
dc.subjectcarbonic anhydraseen_US
dc.subjectmicrobialen_US
dc.subjectN-benzylideneanilineen_US
dc.titleMicrovawe assisted synthesis of N-(methyl and methoxy) benzylidene-4-fluoroaniline derivatives and their carbonic anhydrase I and II inhibition propertiesen_US
dc.typeArticleen_US

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